Actin-binding proteins in nerve cell growth cones
Actin-binding proteins in nerve cell growth cones
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DOI：
10.1254/jphs.cp0070071
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发表时间：
2007-09-01
影响因子：
3.5
通讯作者：
Kohama, Kazuhiro
中科院分区：
文献类型：
--
作者：
Ishikawa, Ryoki;Kohama, Kazuhiro
生长锥是发育中的神经元中位于轴突尖端的细胞内装置，其运动性被认为支配轴突寻路和神经元网络的构建。生长锥含有丰富的肌动蛋白的细胞骨架，它们的动力学是由各种各样的肌动蛋白结合蛋白和马达蛋白。在这篇综述中，我们将重点介绍这些蛋白质的主要功能，它们在体外的相互作用，以及它们在神经细胞生长锥动力学中可能的作用。
The motility of the growth cone, an intracellular apparatus located at the tip of the axon in developing neurons, is thought to govern axonal path-finding and the construction of neuronal networks. Growth cones contain an actin-rich cytoskeleton, and their dynamics are regulated by a wide variety of actin-binding proteins and motor proteins. In this review, we will focus on the principal functions of these proteins, their mutual interactions in vitro, and their possible roles in the dynamics of nerve cell growth cones.