Genetic variation for total fitness in Drosophila melanogaster
Genetic variation for total fitness in Drosophila melanogaster
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DOI：
10.1098/rspb.1997.0027
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发表时间：
1997-02-22
影响因子：
4.7
通讯作者：
Partridge, L
中科院分区：
文献类型：
--
作者：
Fowler, K;Semple, C;Partridge, L
我们测量了12个野生型第三染色体样本的净适合度的杂合效应。黑腹菌通过使野生型染色体与平衡染色体竞争以防止产生重组体来评估对适合度的影响。测量在种群笼环境中进行，其中生活史已经进化，在具有重叠世代的未受干扰的种群中，并且在每条染色体上进行重复测量以控制混杂效应，例如突变累积。我们发现野生型染色体之间的显着差异，在其加性遗传效应的净健身。该系统提供了一个机会，以获得一个准确的估计分布的杂合净健身的影响，不同的健身组件，包括男性交配成功的贡献，和染色体内上位性在健身变化的作用。
We measured the heterozygous effects on net fitness of a sample of 12 wild-type third chromosomes in D. melanogaster. Effects on fitness were assessed by competing the wild-type chromosomes against balancer chromosomes, to prevent the production of recombinants. The measurements were carried out in the population cage environment in which the life history had been evolving, in an undisturbed population with overlapping generations, and replicated measurements were made on each chromosome to control for confounding effects such as mutation accumulation. We found significant variation among the wild type chromosomes in their additive genetic effect on net fitness. The system provides an opportunity to obtain an accurate estimate of the distribution of heterozygous effects on net fitness, the contribution of different fitness components including male mating success, and the role of intra-chromosomal epistasis in fitness variation.