A mild copper-mediated Glaser-type coupling reaction under the novel CuI/NBS/DIPEA promoting system
A mild copper-mediated Glaser-type coupling reaction under the novel CuI/NBS/DIPEA promoting system
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新型 CuI/NBS/DIPEA 促进体系下的温和铜介导 Glaser 型偶联反应
DOI：
10.1016/j.tetlet.2009.04.065
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发表时间：
2009-07-15
影响因子：
1.8
通讯作者：
Liu, Qingfeng
中科院分区：
文献类型：
--
作者：
Li, Lingjun;Wang, Jiuxia;Liu, Qingfeng
首次发现一种简单的铜促进体系CuI/NBS/DIPEA在室温下能有效地促进Glaser偶联反应。在CuI/NBS/DIPEA促进体系下，带有敏感基团的炔缩醛、缩酮、TBDMS、酯、酰胺等可顺利反应生成功能化的1，3-二炔，产率较高。Cul/NBS/DIPEA促进体系在糖和氨基酸结构单元中的成功应用表明了该方法在糖和肽生物分子设计构建中的潜力。(C)2009年由Elsevier Ltd.出版
A simple copper promoting system CuI/NBS/DIPEA was first found to efficiently promote Glaser coupling reaction under ambient temperature. The alkynes with sensitive groups such as acetal and ketal, TBDMS, ester and amide could react smoothly to afford the functionalized 1,3-diynes under the CuI/NBS/DIPEA promoting system in good yields. And the successful application of the Cul/NBS/DIPEA promoting system in sugar and amino acid-building blocks indicated the potential of this method in the construction of designed sugar and peptide biomolecules. (C) 2009 Published by Elsevier Ltd.