Clinical characteristics of patients in a case control study of sarcoidosis
Clinical characteristics of patients in a case control study of sarcoidosis
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DOI：
10.1164/ajrccm.164.10.2104046
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发表时间：
2001-11-15
影响因子：
24.7
通讯作者：
Cherniak, R
中科院分区：
文献类型：
--
作者：
Baughman, RP;Teirstein, AS;Cherniak, R
结节病可能受性别、种族和年龄的影响。一项结节病的病例对照病因学研究(ACCESS)从美国10个临床中心招募了736名在诊断后6个月内患有结节病的患者。使用ACCESS结节病评估系统，我们确定了整个组和按性别、种族和年龄(小于40岁或40岁及以上)区分的亚组的器官受累情况。研究人群在种族(53%白人，44%黑人)，性别(女性，36%男性)和年龄(46%和40岁，54%大于或等于40岁)方面是不同的。女性更有可能有眼部和神经损害(chi(2)=4.74p<；0.05和chi(2)=4.60，p<；0.05)，有结节性红斑(chi(2)=7.28，p<；0.01)，40岁或以上(chi(2)=6.07，p<；0.02)，而男性更有可能患有高血钙症(chi(2)=7.38，p<；0.01)。除结节性红斑(chi(2)=5.47，p<；0.05)、眼(chi(2)=13.8，p<；0.0001)、肝脏(chi(2)=23.3，p<；0.0001)、骨髓(chi(2)=18.8，p<；0.001)和胸外淋巴转移(chi(2)=7.21，p<；0.01)外，黑人受试者更易发生皮肤受累。我们的结论是，结节病的最初表现与性别、种族和年龄有关。
Sarcoidosis may be affected by sex, race, and age. A Case Control Etiologic Study of Sarcoidosis (ACCESS) enrolled 736 patients with sarcoidosis within 6 mo of diagnosis from 10 clinical centers in the United States. Using the ACCESS sarcoidosis assessment system, we determined organ involvement for the whole group and for subgroups differentiated by sex, race, and age (less than 40 yr or 40 yr and older). The study population was heterogeneous in terms of race (53% white, 44% black), sex (64% female, 36% male), and age (46% < 40 yr old, 54% greater than or equal to 40 yr old). Women were more likely to have eye and neurologic involvement (chi (2) = 4.74 p < 0.05 and chi (2) = 4.60, p < 0.05 respectively), have erythema nodosum (chi (2) = 7.28, p < 0.01), and to be age 40 yr or over (chi (2) = 6.07, p < 0.02) whereas men were more likely to be hypercalcemic (chi (2) = 7.38, p < 0.01). Black subjects were more likely to have skin involvement other than erythema nodosum (chi (2) = 5.47, p < 0.05), and eye (chi (2) = 13.8, p < 0.0001), liver (chi (2) = 23.3, p < 0.0001), bone marrow (chi (2) = 18.8, p < 0.001), and extrathoracic lymph node involvement (chi (2) = 7.21, p < 0.01). We conclude that the initial presentation of sarcoidosis is related to sex, race, and age.