Prognosis in childhood epilepsy: additional follow-up of 148 children 15 to 23 years after withdrawal of anticonvulsant therapy.
Prognosis in childhood epilepsy: additional follow-up of 148 children 15 to 23 years after withdrawal of anticonvulsant therapy.
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儿童癫痫的预后：对停止抗惊厥治疗 15 至 23 年后的 148 名儿童进行额外随访。
DOI：
10.1056/nejm198204083061403
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
A. Keller
中科院分区：
文献类型：
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作者：
J. H. Thurston;D. Thurston;B. Hixon;A. Keller
为了评估长期控制后撤回抗惊厥治疗的癫痫儿童的复发风险，我们对 148 名此类儿童进行了为期 15 至 23 年或直至复发的研究。 148 名患者中有 41 名（28%）癫痫复发；其中，35 人（85%）在戒毒后五年内复发。与复发风险增加相关的因素包括控制前癫痫持续时间较长、神经系统功能障碍、杰克逊样癫痫发作或多种癫痫发作类型的组合。我们发现复发风险与癫痫发作年龄、控制前癫痫发作总数、停止治疗时年龄、脑电图异常或癫痫家族史之间没有关联。我们的结论是，不存在上述其他危险因素的儿童在停用抗惊厥药物后很有可能保持无癫痫发作。
To evaluate the risk of relapse in children with epilepsy whose anticonvulsant therapy has been withdrawn after prolonged control, we studied 148 such children for 15 to 23 years or until relapse. Forty-one of the 148 patients (28 per cent) had recurrence of seizures; of these, 35 (85 per cent) had relapses within five years of drug withdrawal. Factors associated with an increased risk of relapse were a long duration of epilepsy before control, neurologic dysfunction, and jacksonian seizures or combinations of seizure types. We found no association between risk of recurrence and age at onset of epilepsy, total number of seizures before control, age at discontinuation of therapy, electroencephalographic abnormalities, or family history of epilepsy. We conclude that children who do not have the additional risk factors noted above have an excellent chance of remaining seizure free after the withdrawal of anticonvulsant drugs.