Study on the function of pharynx & upper esophageal sphincter in globus hystericus
Study on the function of pharynx & upper esophageal sphincter in globus hystericus
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DOI：
10.3748/wjg.v8.i5.952
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发表时间：
2002-10-01
影响因子：
4.3
通讯作者：
Xu, JY
中科院分区：
文献类型：
--
作者：
Sun, J;Xu, B;Xu, JY
目的：咽球肌是一种常见的症状。目前，该病的病理生理机制尚不清楚，常规诊断方法不能正确评价该病。本研究的目的是建立健康志愿者咽压、UES压、咽传递时间的正常值，并比较健康志愿者与咽球症患者咽压、UES压和咽传递时间的差异。方法：24名健康志愿者和32名临床诊断为咽球肌的患者进入研究。测量咽部压力和UES。用显像透视法测定咽传输时间。结果：正常咽压157.81 +/- 63.86 mmHg， UES正常静息压68.33 +/- 37.56 mmHg。患者相应值分别为175.50 +/- 93.47 mmHg和71.38 +/- 41.42 mmHg。正常对照组咽部转移时间1.44±0.30 s，其中小囊内钡淤积4例，梨状窦内钡淤积1例。未发现喉部穿透或误吸。患者组咽部穿越时间为1.37±0.41 s，其中小囊钡淤积6例，梨状窦钡淤积5例。喉部穿透9例，误吸2例。两组患者咽部压力、UES及咽部穿越时间比较，差异均无统计学意义。但喉头穿透和咽球肌之间存在联系。结论：咽部x线检查显示了咽球症患者咽功能障碍的特殊表现。大多数患者的UES压力正常。因此，我们没有发现UES高渗作为球咽喉炎的病因因素的作用。
AIM: Globus pharyngeus is not an uncommon symptom. Presently, its unclear dated pathophysiology remains unclear and the disease can not be evaluated correctly with routine diagnostic methods. The objective of this study is to establish the normal values of pharyngeal and UES pressure, pharyngeal transit time in healthy volunteers and to compare the differences between healthy volunteers and patients with globus pharyngeus.METHODS: Twenty-four healthy volunteers and thirty-two patients clinically diagnosed as globus pharyngeus entered the study. Pressures of pharynx and UES were measured. Pharyngeal transit time was measured by videofluoroscopic procedure.RESULTS: Normal pressure of pharynx, and normal resting pressure of UES were 157.81 +/- 63.86 mmHg and 68.33 +/- 37.56 mmHg, respectively. The corresponding values in the patients were 175.50 +/- 93.47 mmHg and 71.38 +/- 41.42 mmHg. The pharyngeal transit time was 1.44 +/- 0.30 s in normal control group, among them there were 4 cases with stasis of barium in the valleculae and one in the piriform sinus. No laryngeal penetration or aspiration was found. In the patient group, the pharyngeal transit time was 1.37 +/- 0.41 s, among them there were 6 cases with stasis of barium in the valleculae and 5 in the piriform sinus. 9 cases had laryngeal penetration and 2 had aspiration. There were no statistical differences of pressures of pharynx, UES and the pharyngeal transit time between the two groups. But there was an association between laryngeal penetration and globus pharyngeus.CONCLUSION: Radiographic examination of the pharynx show specific findings of pharyngeal dysfunction in patients with globus pharyngeus. UES pressure is normal in most patients. Hence, we find no role for UES hypertonicity as an etiologic factor in globus pharyngeus.