Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton.
Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton.
复制标题
动力形态发生：细胞粘附和细胞骨架界面的多尺度挑战。
DOI：
10.1091/mbc.e21-09-0452
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发表时间：
2022-07-01
影响因子：
3.3
通讯作者：
Peifer, Mark
中科院分区：
文献类型：
--
作者：
Fernandez-Gonzalez, Rodrigo;Peifer, Mark
动物王国的定义特征之一是细胞改变形状和移动的能力。这是胚胎和胚后发育、组织稳态、再生和伤口愈合的基础。细胞的形状变化和运动性需要细胞的力产生机制在细胞-细胞和细胞-细胞外基质连接处与质膜连接。肌动球蛋白细胞骨架与细胞-细胞粘附连接处的连接需要具有弹性和动态性，以防止胚胎形态发生的戏剧性事件中组织破裂。在过去的十年中，新的见解从根本上改变了早期的简单范式，建议通过钙粘蛋白-连环蛋白复合物作为连接-细胞骨架相互作用的分子机制的简单线性连接。在这个角度，我们提供了一个简短的概述，我们目前的知识状态，然后集中在选定的例子，突出我们认为是在我们的领域和方法，提供令人兴奋的新见解，在多个尺度从原子结构到组织力学的主要悬而未决的问题。
Among the defining features of the animal kingdom is the ability of cells to change shape and move. This underlies embryonic and postembryonic development, tissue homeostasis, regeneration, and wound healing. Cell shape change and motility require linkage of the cell’s force-generating machinery to the plasma membrane at cell–cell and cell–extracellular matrix junctions. Connections of the actomyosin cytoskeleton to cell–cell adherens junctions need to be both resilient and dynamic, preventing tissue disruption during the dramatic events of embryonic morphogenesis. In the past decade, new insights radically altered the earlier simple paradigm that suggested simple linear linkage via the cadherin–catenin complex as the molecular mechanism of junction–cytoskeleton interaction. In this Perspective we provide a brief overview of our current state of knowledge and then focus on selected examples highlighting what we view as the major unanswered questions in our field and the approaches that offer exciting new insights at multiple scales from atomic structure to tissue mechanics.