Pathfinding by retinal ganglion cell axons: transplantation studies in genetically and surgically blind mice.
Pathfinding by retinal ganglion cell axons: transplantation studies in genetically and surgically blind mice.
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视网膜神经节细胞轴突寻路：遗传和手术失明小鼠的移植研究。
DOI：
10.1002/cne.903560313
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Hankin,MH
中科院分区：
文献类型：
--
作者：
Lund,RD;Hankin,MH
视神经轴突表现出一个高度刻板的颅内过程，以达到脑干的视觉中心。在这里，我们研究的过程中，随后由胚胎视网膜轴突植入新生儿眼发育迟缓突变小鼠，其中有没有以前的视觉中枢神经支配。视网膜位于脑干腹外侧，邻近视束的正常部位，向同侧上级丘背外侧发送轴突，它们沿着支配其他一些皮质下视觉中枢。有些出乎意料的是，轴突也会腹侧穿过视交叉上核的水平，或者不太频繁地穿过乳头体的尾侧，沿着视束的路线并支配对侧的视觉中心。视网膜植入沿着内囊的路线发出轴突，轴突跟随投射纤维穿过纹状体以神经支配外侧膝状体核和其他视核。这些移植物也出现项目的外侧部分的ventrobasal nucleus的thalam.The结果表明，先前存在的光学投影是不必要的轴突来自异位视网膜达到视觉核，不仅在一侧的植入，而且在对侧的大脑。这些生长的轴突所遵循的线索在时间上似乎是稳定的。事实上，轴突也可以遵循高度异常的路线，如通过内囊，以达到脑干中的目标核，这表明正常的视通路不是一个强制性的路线为视神经生长。© 1995 Wiley利斯公司
Optic axons show a highly stereotypical intracranial course to attain the visual centers of the brainstem. Here we examine the course followed by axons arising from embryonic retinae implanted in neonatal ocular retardation mutant mice in which there had been no prior innervation of the visual centers. Retinae placed on the ventrolateral brainstem adjacent to the normal site of the optic tract send axons dorsolaterally toward the ipsilateral superior colliculus, which they innervate along with a number of other subcortical visual centers. Somewhat unexpectedly, axons also course ventrally to cross at the level of the suprachiasmatic nucleus or, less frequently, caudal to the mammillary body to follow the route of the optic tract and innervate contralateral visual centers. Retinae implanted along the course of the internal capsule emit axons that follow projection fibers through the striatum to innervate the lateral geniculate nucleus and other optic nuclei. These grafts also appear to project to the lateral part of the ventrobasal nucleus of the thalamus.The results show that prior existence of an optic projection is not necessary for axons derived from ectopic retinae to attain visual nuclei, not only on the side of implantation but also on the contralateral side of the brain. The cues that these growing axons follow appear to be stable temporally. The fact that axons can also follow highly anomalous routes, such as through the internal capsule, to attain target nuclei in the brainstem suggests that the normal optic pathway is not an obligatory route for optic outgrowth. © 1995 Wiley‐Liss, Inc.