Experimental study on anti-inflammatory and immuno-regulating effect of kirenol
Experimental study on anti-inflammatory and immuno-regulating effect of kirenol
复制标题
DOI：
--
复制
发表时间：
2005
影响因子：
--
通讯作者：
Xin Hong-ling
中科院分区：
文献类型：
--
作者：
Xin Hong-ling
目的研究奇瑞诺的抗炎和免疫调节作用。 (方法)采用弗氏完全佐剂制作佐剂性关节炎大鼠模型，观察佐剂性关节炎大鼠足肿胀、脾淋巴细胞增殖及T淋巴细胞亚群比例的变化。采用二甲苯致耳水肿模型和棉球肉芽肿模型评价奇瑞诺的抗炎作用，并通过小鼠耳廓肿胀迟发型超敏反应、小鼠血清溶血素水平测试和碳清除率评价奇瑞诺对特异性和非特异性免疫反应的影响。结果 Kirenol 可抑制佐剂性关节炎大鼠足肿胀，促进脾淋巴细胞增殖，调节 T 淋巴细胞亚群比例，抑制小鼠耳水肿、大鼠肉芽肿重量和正常小鼠的特异性免疫反应。 结论 Kirenol 可控制佐剂关节炎大鼠原发性和继发性足肿胀，抑制急慢性炎症，调节免疫功能。
Objective To study the anti-inflammatory and immuno-regulating effect of kirenol. (Methods) Adjuvant arthritis rat model was made by means of Freunds complete adjuvant, then the changes of paw swelling, proliferation of splenic lymphocyte and T lymphocyte subpopulation ratio of adjuvant arthritis rats were observed. The anti-inflammatory effect of kirenol was evaluated using ear edema model induced by xylene and granuloma model induced by cotton balls, and further the effect of kirenol on specific and non-specific immune response was evaluated by delayed hypersensitivity of murine auricle swelling and serum hemolysin level test and carbon clearance rate in mice. Results Kirenol can inhibit paw swelling, boost up the proliferation of splenic lymphocyte of adjuvant arthritis rats, regulate T lymphocyte subpopulation ratio, and also can inhibit ear edema in mice, granuloma weight in rats, and specific immune response of normal mice.Conclusion Kirenol can control the primary and secondary paw swelling of adjuvant arthritis rats, inhibit acute and chronic inflammation, and regulate immunologic function.