Triglyceride turnover in severe chronic non-nephrotic renal failure.
Triglyceride turnover in severe chronic non-nephrotic renal failure.
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严重慢性非肾病性肾衰竭中的甘油三酯周转。
DOI：
10.1016/0026-0495(78)90130-0
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. Birkenhäger
中科院分区：
文献类型：
--
作者：
L. Verschoor;R. Lammers;J. Birkenhäger
对12例慢性非肾病肾功能衰竭患者(肌酐清除量3.5~11ml/min)和8例正常对照的血浆甘油三酯转换率进行了研究。患者空腹甘油三酯浓度和血浆甘油三酯绝对转化率显著升高，而部分转化率显著降低。在肌酐清除率最高的患者中，发现甘油三酯转换率升高，部分清除率接近正常，这表明这些患者的甘油三酯合成率增加。然而，大多数患者表现出清除机制受损是高甘油三酯血症的主要原因。
In 12 patients with chronic non-nephrotic renal failure (creatinine clearance 3.5–11 ml/min) and 8 control subjects, plasma triglyceride turnover was studied. The patients showed significantly increased fasting triglyceride concentrations and absolute plasma triglyceride turnover rates, while the fractional turnover rate was significantly decreased. The finding of an elevated triglyceride turnover rate with a near normal fractional removal rate in the patients with the highest creatinine clearance suggests the involvement of an increased triglyceride synthesis rate in these patients. However, most patients showed an impaired removal mechanism as the major cause of the hypertriglyceridemia.