Increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin.
Increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin.
复制标题
与拉氧头孢、哌拉西林、氯霉素和克林霉素相比，妥布霉素、庆大霉素和阿米卡星对厌氧菌的最低抑制浓度增加。
作者：
K. Tack;L. Sabath
在常规好氧和厌氧条件下测定了9属93种微生物的最低抑菌浓度(MIC)。在厌氧条件下，氨基糖苷类药物阿米卡星、庆大霉素和妥布霉素的MIC显著增加。妥布霉素对厌氧菌引起的抗菌活性丧失最为敏感。葡萄球菌的MIC比革兰氏阴性杆菌的MIC增加了更多，但即使在后一组中，变形杆菌的MIC增加也大于沙门氏菌、克雷伯氏菌和大肠埃希菌。拉托莫夫、哌拉西林、氯霉素或克林霉素的厌氧活性与有氧活性没有变化。
Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under anaerobic conditions. Tobramycin was most sensitive to the loss of antimicrobial activity with anaerobiasis. MICs for staphylococci were increased by a higher factor than were MICs for gram-negative rods, but even within the latter group increases in MICs for Proteus species were greater than for Salmonella, Klebsiella and Escherichia coli. No change of anaerobic versus aerobic activity was seen for latamoxef, piperacillin, chloramphenicol, or clindamycin.