Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine
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DOI：
10.1126/science.199941
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发表时间：
1977-11
期刊：
影响因子：
56.9
通讯作者：
J. E. Silva;P. Larsen
中科院分区：
文献类型：
--
作者：
J. E. Silva;P. Larsen
一个很好的相关性，观察核三碘甲状腺原氨酸（T3）和随后的抑制促甲状腺激素（TSH）后，单次静脉注射T3甲状腺切除（甲状腺功能减退）大鼠。在注射甲状腺素（T4）后1小时和2小时，在急性抑制TSH方面与T3剂量相等，在垂体核中发现相同数量的T3。几乎没有核T4，血浆T3在T4注射后的这些短时间间隔内可以忽略不计。这些结果表明，甲状腺功能减退大鼠TSH释放的抑制发生的相互作用的T3与核受体的促甲状腺激素。注射T4后，在核中发现的T3来自垂体内快速的单脱碘。
An excellent correlation was observed between nuclear triiodothyronine (T3) and the ensuing suppression of thyrotropin (TSH) after a single intravenous injection of T3 to thyroidectomized (hypothyroid) rats. At 1 and 2 hours after injection of thyroxine (T4), in amounts equally potent to the administered T3 in terms of acute suppression of TSH, the same quantities of T3 were found in the pituitary nuclei. Virtually no nuclear T4 was present, and plasma T3 was negligible at these short intervals after T4 injection. These results suggest that suppression of TSH release in hypothyroid rats occurs by interaction of T3 with the nuclear receptor of the thyrotroph. After T4 injection, the T3 found in the nucleus is derived from rapid intrapituitary monodeiodination.