Plasmablastic Lymphoma and Related Disorders
Plasmablastic Lymphoma and Related Disorders
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DOI：
10.1309/ajcpv1i2qwkzknjh
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发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Dogan, Ahmet
中科院分区：
文献类型：
--
作者：
Hsi, Eric D.;Lorsbach, Robert B.;Dogan, Ahmet
具有浆细胞特征的B细胞淋巴瘤是一组异质性淋巴瘤。虽然它们可能具有重叠的形态学或免疫表型特征，但对于一些允许将其识别为不同实体的患者，存在不同的临床病理学或分子遗传学特征。2009年血液病理学学会/欧洲血液病理学协会研讨会的第2次会议讨论了浆细胞淋巴瘤（PBL）和相关疾病的主题。主题包括人类疱疹病毒8相关的Castleman病和PBL，发生在HIV感染背景下的PBL，间变性大细胞淋巴瘤激酶+弥漫性大B细胞淋巴瘤，以及其他具有浆细胞或浆细胞特征的淋巴瘤。在这份报告中，我们回顾了PBL和相关疾病的背景下提交的情况下，并说明了关键的诊断点，突出有争议的领域，并提供建议的功能，应评估和术语，可能会使用时，处理这些淋巴瘤。
B-cell lymphomas with plasmablastic features are a heterogeneous group of lymphomas. While they may share overlapping morphologic or immunophenotypic features, distinct clinicopathologic or molecular genetic features exist for some that have allowed their recognition as distinct entities. Session 2 of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop dealt with the theme of plasmablastic lymphomas (PBLs) and related disorders. Topics included human herpesvirus 8 associated Castleman disease and PBLs, PBLs occurring in the setting of HIV infection, anaplastic large cell lymphoma kinase+ diffuse large B-cell lymphoma, and other lymphomas with plasmablastic or plasmacytic features. In this report, we review PBLs and related disorders in the context of submitted cases and illustrate key diagnostic points, highlight controversial areas, and provide recommendations on features that should be assessed and terminology that might be used when dealing with these lymphomas.