Reducing the global burden of cardiovascular disease: the role of risk factors.
Reducing the global burden of cardiovascular disease: the role of risk factors.
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DOI：
10.1111/j.1520-037x.2002.00564.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Gaziano, J Michael
中科院分区：
文献类型：
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作者：
Levenson, James W;Skerrett, Patrick J;Gaziano, J Michael
在上个世纪，心血管疾病（CVD）已经从一个相对较小的疾病在世界范围内迅速发展成为发病率和死亡率的主要原因。预计到2020年，心血管疾病将超过传染病，成为世界上导致死亡和残疾的主要原因。心血管疾病相对重要性的增加部分是由于公共卫生措施和医疗保健的改善导致寿命延长和其他原因造成的死亡率降低。然而，CVD日益增加的全球影响的很大一部分可归因于经济、社会和文化的变化，这些变化导致了CVD危险因素的增加。这些变化在发展中国家最为明显。由于世界上大多数人口生活在发展中国家，这些国家心血管疾病发病率的上升是全球心血管疾病持续急剧增长背后的驱动力。为了减轻全球心血管疾病激增的影响，试图了解和减少全球心血管疾病危险因素的增加将是至关重要的。在这篇综述中，作者描述了导致全球心血管疾病流行的变化，特别关注了既定风险因素的贡献及其对世界各经济部门心血管疾病增长的影响。这组作者概述了不同经济部门的国家面临的主要挑战，并讨论了以减少心血管疾病的全球负担为目标应对这些挑战的方法。
During the last century, cardiovascular disease (CVD) has burgeoned from a relatively minor disease worldwide to a leading cause of morbidity and mortality. By 2020 it is projected that CVD will surpass infectious disease as the worlds leading cause of death and disability. Some of this increase in the relative importance of CVD is due to improved public health measures and medical care leading to longer life spans and reduced mortality from other causes. However, a substantial portion of the increasing global impact of CVD is attributable to economic, social, and cultural changes that have led to increases in risk factors for CVD. These changes are most pronounced in the countries comprising the developing world. Because the majority of the worlds population lives in the developing world, the increasing rate of CVD in these countries is the driving force behind the continuing dramatic worldwide increase in CVD. In order to blunt the impact of the global explosion in CVD, it will be crucial to attempt to understand and reduce the global increase in CVD risk factors. In this review, the authors describe the changes responsible for the global epidemic of CVD, with particular attention to the contributions of established risk factors and their impact on the growth of CVD among the worlds various economic sectors. The authors outline the major challenges facing countries in different economic sectors, and discuss ways to address these challenges with the goal of reducing the global burden of CVD.