Randomised controlled trial of interpersonal psychotherapy and cognitive-behavioural therapy for depression
Randomised controlled trial of interpersonal psychotherapy and cognitive-behavioural therapy for depression
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DOI：
10.1192/bjp.bp.106.024729
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发表时间：
2007-06-01
影响因子：
10.5
通讯作者：
Joyce, Peter R.
中科院分区：
文献类型：
--
作者：
Luty, Suzanne E.;Carter, Janet D.;Joyce, Peter R.
背景人际心理治疗和认知行为治疗（CBT）被认为是治疗抑郁症的有效方法。目的比较人际关系心理治疗与认知行为疗法对门诊抑郁症患者的疗效，探讨其对重度抑郁症的治疗效果（Montgomery-Asberg抑郁评定量表（MADRS）评分高于30），方法对177名主轴1诊断为重度抑郁症的患者进行随机临床试验，接受16周的治疗，包括8-19次会议。结果两种心理疗法在总体上无显著性差异，但CBT对重度抑郁症的疗效优于人际心理疗法，对轻中度抑郁症的疗效与人际心理疗法相当。忧郁症并不能预测对任何一种心理治疗的不良反应。结论两种疗法对抑郁症同样有效，但CBT可能是重度抑郁症的首选。
Background Interpersonal psychotherapy and cognitive-behavioural therapy (CBT) are established as effective treatments for major depression. Controversy remains regarding their effectiveness for severe and melancholic depression.Aims To compare the efficacy of interpersonal psychotherapy and CBT in people receiving out-patient treatment for depression and to explore response in severe depression (Montgomery-Asberg Depression Rating Scale (MADRS) score above 30), and in melancholic depression.Method Randomised clinical trial of 177 patients with a principal Axis 1 diagnosis of major depressive disorder receiving 16 weeks of therapy comprising 8-19 sessions. Primary outcome was improvement in MADRS score from baseline to end of treatment.Results There was no difference between the two psychotherapies in the sample as a whole, but CBT was more effective than interpersonal psychotherapy in severe depression, and the response was comparable with that for mild and moder-ate depression. Melancholia did not predict poor response to either psychotherapyConclusions Both therapies are equally effective for depression but CBT may be preferred in severe depression.Declaration of interest None.