Differentiation of NK1 and NK2 cells
Differentiation of NK1 and NK2 cells
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DOI：
10.1615/critrevimmunol.v25.i5.20
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发表时间：
2005-01-01
影响因子：
1.3
通讯作者：
Nakayama, T
中科院分区：
文献类型：
--
作者：
Kimura, MY;Nakayama, T
1 型自然杀伤 (NK1)/NK2 术语被提议作为 CD4 T 细胞的 1 型辅助性 T (Th1)/Th2 亚群的类比。除了众所周知的产生 IFN-γ 的 NK1 细胞外，最近积累的证据表明 NK2 细胞的存在及其调节功能，NK2 细胞产生 2 型细胞因子，例如 IL-5 和 IL-13。大多数关于 NK1/NK2 亚群产生细胞因子的研究都是在人体系统中进行的。最近，建立了小鼠体外NK1/NK2细胞分化体系。已提出线性“2-0-1”模型用于 NK1/NK2 细胞亚群的分化，但与 Th1/Th2 细胞分化相当的分支 NK1/NK2 细胞分化模型仍然是一种可能的解释。在这篇综述中，我们总结了表明 NK1/NK2 细胞独特特征的证据，并讨论了上述两种 NK 细胞分化模型。此外，我们还指出了调节 NK 细胞和 CD8 T 细胞细胞因子产生的转录因子表达的有趣相似之处。
Natural killer type-1 (NK1)/NK2 terminology was proposed as an analogy to T helper type-1 (Th1)/Th2 subsets of CD4 T cells. In addition to well recognized IFN-gamma-producing NK1 cells, recent accumulating evidence suggests the presence and the regulatory function of NK2 cells, which produce type-2 cytokines, such as IL-5 and IL-13. Most studies on the production of cytokines by NK1/NK2 subsets have been performed in the human system. Recently, a mouse in vitro NK1/NK2 cell differentiation system was established. A linear "2-0-1" model has been proposed for the differentiation of NK1/NK2 cell subsets, but the branching NK1/NK2 cell differentiation model, comparable to Th1/Th2 cell differentiation, remains a likely explanation. In this review, we summarize the evidence indicating the unique features of NK1/NK2 cells and discuss the above two NK cell differentiation models. In addition, we point to interesting similarities in the expression of transcription factors that regulate cytokine production in NK cells and CD8 T cells.