Regulation of NLR stability in plant immunity
Regulation of NLR stability in plant immunity
复制标题
植物免疫中 NLR 稳定性的调节
DOI：
10.15302/j-fase-2018248
复制
发表时间：
2019-05
影响因子：
3.7
通讯作者：
沈前华
中科院分区：
文献类型：
--
作者：
王涛;Jiaxin Li;沈前华
植物核苷酸结合域和亮氨酸重复序列（NLR）受体直接或间接识别病原体效应子，介导先天免疫应答。NLR介导的免疫也对植物生长和发育以及产量和存活有直接影响。因此，NLR蛋白的水平在植物中受到复杂的控制，以平衡防御反应和其他过程。近年来，泛素化26 S蛋白酶体系统和HSP 90分子伴侣在NLR稳定性调控中发挥了重要作用。蛋白质降解的N-末端规则途径也与NLR稳定性直接相关。本文综述了近几年来NLR稳定性和周转调控的研究进展，重点介绍了NLR的关键组分和调控途径。
Plant nucleotide binding domain and leucinerich repeat (NLR) receptors recognize pathogen effectors directly or indirectly and mediate innate immune responses. NLR-mediated immunity also has direct impacts on plant growth and development, as well as yield and survival. The levels of NLR proteins are therefore intricately controlled in plants to balance defense responses and other processes. In recent years, the.ubiquitination-26S proteasome system and the HSP90 chaperones have emerged as having key functions in the.regulation of NLR stability. The N-end rule pathway of protein degradation is also directly linked to NLR stability..Recent progress in the regulation of NLR stability and turnover is summarized here, focusing on the key.components and pathways.