PITTING FUNCTION OF SPLEEN IN MALARIA - ULTRASTRUCTURAL OBSERVATIONS
PITTING FUNCTION OF SPLEEN IN MALARIA - ULTRASTRUCTURAL OBSERVATIONS
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DOI：
10.1126/science.177.4044.175
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
MEAD, ML
中科院分区：
文献类型：
--
作者：
SCHNITZER, B;SODEMAN, T;MEAD, ML
对感染疟原虫的猴子脾脏的超微结构研究表明，脾脏可以从红细胞中清除或“坑”出疟原虫。该函数可以解释外周血中未寄生的球形红细胞的存在，并可以部分解释实验诱导疟疾动物中过度溶血和寄生红细胞数量之间的差异。
Ultrastructural studies of spleens from monkeys infected withPlasmodium knowlesisuggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.