Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial
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DOI：
10.1016/j.beth.2012.01.001
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发表时间：
2012-09-01
期刊：
影响因子：
3.7
通讯作者：
Barlow, David H.
中科院分区：
文献类型：
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作者：
Farchione, Todd J.;Fairholme, Christopher P.;Barlow, David H.
本研究进一步评估情绪障碍跨诊断治疗统一方案（UP）的有效性。一项随机对照试验（RCT）纳入了37例主要诊断为焦虑症的患者的诊断异质性临床样本，该试验涉及多达18次治疗和6个月的随访期。患者被随机分配接受立即治疗与UP（n=26）或延迟治疗后，16周的等待列表控制期（WLC; n=11）。UP导致临床严重程度，抑郁和焦虑的一般症状，消极和积极影响的水平，以及跨诊断的日常功能的症状干扰的措施的显着改善。相比之下，WLC条件下的参与者在16周的等待期后几乎没有变化。UP治疗的效果在6个月的随访期内得以维持。这项随机对照试验的结果为UP治疗焦虑和共病抑郁障碍的疗效提供了额外的证据，并为治疗情绪障碍的跨诊断方法提供了额外的支持。
This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP (n=26) or delayed treatment, following a 16-week wait-list control period (WLC; n=11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.