The significance of caudate volume for age-related associative memory decline
The significance of caudate volume for age-related associative memory decline
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DOI：
10.1016/j.brainres.2015.06.026
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发表时间：
2015-10-05
期刊：
影响因子：
2.9
通讯作者：
Sammer, G.
中科院分区：
文献类型：
--
作者：
Bauer, E.;Toepper, M.;Sammer, G.
衰老伴随着几个大脑区域的同性恋物质（GM）体积的减少和不同认知领域的认知能力下降而沿着。此外，区域GM体积与老年人的特定认知子过程有关。然而，目前尚不清楚老年人的哪些区域变化与认知能力下降直接相关。此外，大多数关于这一主题的研究集中在海马和前额叶脑区及其与记忆和执行功能的关系。有趣的是，只有少数研究报告了纹状体脑容量与认知能力之间的关联。这是令人惊讶的，纹状体结构（1）高度受年龄的影响，（2）参与不同的神经回路，服务于完整的认知。为了解决这些问题，基于体素的形态测定法（VBM）被用来分析GM体积在18个年轻人和18个老年人。此外，从不同的神经心理学测试电池的几个神经心理学测试，以评估广泛的认知领域。老年人表现出较少的GM体积比年轻的成年人在额叶，纹状体和小脑区域。在老年人组中，纹状体GM体积和记忆性能之间以及前额叶/颞叶GM体积和执行功能之间存在显着相关性。与老年人的局部萎缩和认知能力相关的脑区之间唯一的直接重叠是在右尾状核中发现的：老年人的尾状核体积相对于年轻人减少。此外，尾状核体积与老年人的联想记忆准确性呈正相关，老年人在各自的联想记忆任务中表现出比年轻人更差的表现。总之，目前的研究结果表明尾状核与衰老大脑中联想记忆下降的相关性。(C)2015年，作者。由爱思唯尔公司出版
Aging comes along with reduced gay matter (GM) volume in several cerebral areas and with cognitive performance decline in different cognitive domains. Moreover, regional GM volume is linked to specific cognitive sub processes in older adults. However, it remains unclear which regional changes in older individuals are directly associated with decreased cognitive performance. Moreover, most of the studies on this topic focused on hippocampal and prefrontal brain regions and their relation to memory and executive functioning. Interestingly, there are only a few studies that reported an association between striatal brain volume and cognitive performance. This is insofar surprising that striatal structures are (1) highly affected by age and (2) involved in different neural circuits that serve intact cognition. To address these issues, voxel-based morphometry (VBM) was used to analyze GM volume in 18 younger and 18 older adults. Moreover, several neuropsychological tests from different neuropsychological test batteries were applied to assess a broad range of cognitive domains. Older adults showed less GM volume than younger adults within frontal, striatal, and cerebellar brain regions. In the group of older adults, significant correlations were found between striatal GM volume and memory performance and between prefrontal/temporal GM volume and executive functioning. The only direct overlap between brain regions associated with regional atrophy and cognitive performance in older adults was found for the right caudate: older adults showed reduced caudate volume relative to younger adults. Moreover, caudate volume was positively correlated with associative memory accuracy in older adults and older adults showed poorer performances than younger adults in the respective associative memory task. Taken together, the current findings indicate the relevance of the caudate for associative memory decline in the aging brain. (C) 2015 The Authors. Published by Elsevier B.V.