Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria.
Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria.
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DOI：
10.4269/ajtmh.13-0665
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Brittenham GM
中科院分区：
文献类型：
--
作者：
Laothamatas J;Sammet CL;Golay X;Van Cauteren M;Lekprasert V;Tangpukdee N;Krudsood S;Leowattana W;Wilairatana P;Swaminathan SV;DeLaPaz RL;Brown TR;Looareesuwan S;Brittenham GM
Patients with acute uncomplicated Plasmodium falciparum malaria have no evident neurologic disorder, vital organ dysfunction, or other severe manifestations of infection. Nonetheless, parasitized erythrocytes cytoadhere to the endothelium throughout their microvasculature, especially within the brain. We aimed to determine if 3 Tesla magnetic resonance imaging studies could detect evidence of cerebral abnormalities in these patients. Within 24 hours of admission, initial magnetic resonance imaging examinations found a lesion with restricted water diffusion in the mid-portion of the splenium of the corpus callosum of 4 (40%) of 10 male patients. The four patients who had a splenial lesion initially had evidence of more severe hemolysis and thrombocytopenia than the six patients who had no apparent abnormality. Repeat studies four weeks later found no residua of the lesions and resolution of the hematologic differences. These observations provide evidence for acute cerebral injury in the absence of severe or cerebral malaria.
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影响因子：
3.6
作者：
Idro R;Marsh K;John CC;Newton CR
通讯作者：
Newton CR
影响因子：
3.3
作者：
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通讯作者：
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DOI：
10.1016/j.trstmh.2004.11.017
发表时间：
2005-08-01
影响因子：
2.2
作者：
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影响因子：
28.2
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影响因子：
82.9
作者：
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