Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures.
Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures.
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DOI：
10.1371/journal.pone.0263976
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Gimzewski JK
中科院分区：
文献类型：
--
作者：
Dunham CS;Mackenzie ME;Nakano H;Kim AR;Juda MB;Nakano A;Stieg AZ;Gimzewski JK
幂定律是几个科学学科感兴趣的，因为它们可以提供关于给定系统的基本动力学(例如，标度不变性和自相似性)的重要信息。由于幂定律作为心功能不全的潜在指标越来越受到心脏科学的关注，因此在评价幂定律时采用严格、标准化的分析方法是至关重要的。本研究比较了目前在凝聚态物理、地球科学、神经科学和心脏病学领域中使用的方法，以便为评估干细胞来源的心肌细胞培养中的幂定律提供一个可靠的分析框架。在这些细胞培养中观察到的一个潜在的遵循幂定律的现象是起搏器易位，即2D细胞培养中起搏器区域的空间和时间不稳定性。使用越来越严格的方法对移位数据进行了幂定律分析，以说明分析稳健性的差异如何导致误导性的幂定律解释。非稳健的方法得出结论，起搏器的移位遵循幂定律，而稳健的方法令人信服地证明它们遵守双截断的幂定律。这项研究的结果强调了在心肌细胞培养的幂定律分析中使用综合方法的重要性。
Power laws are of interest to several scientific disciplines because they can provide important information about the underlying dynamics (e.g. scale invariance and self-similarity) of a given system. Because power laws are of increasing interest to the cardiac sciences as potential indicators of cardiac dysfunction, it is essential that rigorous, standardized analytical methods are employed in the evaluation of power laws. This study compares the methods currently used in the fields of condensed matter physics, geoscience, neuroscience, and cardiology in order to provide a robust analytical framework for evaluating power laws in stem cell-derived cardiomyocyte cultures. One potential power law-obeying phenomenon observed in these cultures is pacemaker translocations, or the spatial and temporal instability of the pacemaker region, in a 2D cell culture. Power law analysis of translocation data was performed using increasingly rigorous methods in order to illustrate how differences in analytical robustness can result in misleading power law interpretations. Non-robust methods concluded that pacemaker translocations adhere to a power law while robust methods convincingly demonstrated that they obey a doubly truncated power law. The results of this study highlight the importance of employing comprehensive methods during power law analysis of cardiomyocyte cultures.
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影响因子：
16.6
作者：
Funakoshi S;Fernandes I;Mastikhina O;Wilkinson D;Tran T;Dhahri W;Mazine A;Yang D;Burnett B;Lee J;Protze S;Bader GD;Nunes SS;Laflamme M;Keller G
通讯作者：
Keller G
DOI：
10.1073/pnas.0307156101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Aon, MA;Cortassa, S;O'Rourke, B
通讯作者：
O'Rourke, B
影响因子：
37.8
作者：
Bigger, JT;Steinman, RC;Cohen, RJ
通讯作者：
Cohen, RJ
影响因子：
2.3
作者：
Deluca, Anna;Corral, Alvaro
通讯作者：
Corral, Alvaro
影响因子：
4.6
作者：
Ribeiro da Silva A;Neri EA;Turaça LT;Dariolli R;Fonseca-Alaniz MH;Santos-Miranda A;Roman-Campos D;Venturini G;Krieger JE
通讯作者：
Krieger JE