Central cancellation of self-produced tickle sensation
Central cancellation of self-produced tickle sensation
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DOI：
10.1038/2870
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发表时间：
1998-11-01
影响因子：
25
通讯作者：
Frith, CD
中科院分区：
文献类型：
--
作者：
Blakemore, SJ;Wolpert, DM;Frith, CD
与外部产生的相同刺激相比，自我产生的触觉刺激被认为不那么痒。我们使用功能磁共振成像来检查受试者经历自身产生或外部产生的触觉刺激时的神经反应。当外部产生刺激时，体感皮层会更加活跃。在小脑中，与不产生触觉刺激的运动相比，与产生触觉刺激的运动相关的活动较少。这种差异表明小脑参与预测运动的特定感觉后果，提供用于取消对自身产生的刺激的感觉反应的信号。
A self-produced tactile stimulus is perceived as less ticklish than the same stimulus generated externally. We used fMRI to examine neural responses when subjects experienced a tactile stimulus that was either self-produced or externally produced. More activity was found in somatosensory cortex when the stimulus was externally produced. In the cerebellum, less activity was associated with a movement that generated a tactile stimulus than with a movement that did not. This difference suggests that the cerebellum is involved in predicting the specific sensory consequences of movements, providing the signal that is used to cancel the sensory response to self-generated stimulation.