The Framingham Heart Study, on its way to becoming the gold standard for Cardiovascular Genetic Epidemiology?
The Framingham Heart Study, on its way to becoming the gold standard for Cardiovascular Genetic Epidemiology?
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DOI：
10.1186/1471-2350-8-63
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发表时间：
2007-10-04
影响因子：
--
通讯作者：
Jaquish CE
中科院分区：
文献类型：
--
作者：
Jaquish CE
Framingham心脏研究成立于1948年，目的是研究波士顿以外一个小镇的心血管疾病的流行病学，已成为心血管流行病学的全球标准。它是世界上最长，最全面的多代研究之一。诸如吸烟和高胆固醇对心脏病的影响的结果来自弗雷明汉心脏研究。在出版时，这些是新颖的心血管疾病（CVD）风险因素，现在它们是美国治疗和预防的基础。 Framingham现在的研究是否正在成为CVD遗传流行病学的黄金标准？今天的新遗传发现会成为明天的医疗保健标准吗？总结了全基因组关联研究结果（GWAS）的随附文章，使读者首先了解了可能性。
The Framingham Heart Study, founded in 1948 to examine the epidemiology of cardiovascular disease in a small town outside of Boston, has become the worldwide standard for cardiovascular epidemiology. It is among the longest running, most comprehensively characterized multi-generational studies in the world. Such seminal findings as the effects of smoking and high cholesterol on heart disease came from the Framingham Heart Study. At the time of publication these were novel cardiovascular disease (CVD) risk factors, now they are the basis of treatment and prevention in the US. Is the Framingham study now on it's way to becoming the gold standard for genetic epidemiology of CVD? Will the novel genetic findings of today become the health care standards of tomorrow? The accompanying articles summarizing the results of genome-wide association studies (GWAS) give the reader a first glimpse into the possibilities.
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影响因子：
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作者：
Kathiresan S;Manning AK;Demissie S;D'Agostino RB;Surti A;Guiducci C;Gianniny L;Burtt NP;Melander O;Orho-Melander M;Arnett DK;Peloso GM;Ordovas JM;Cupples LA
通讯作者：
Cupples LA
影响因子：
56.9
作者：
Hinds, DA;Stuve, LL;Cox, DR
通讯作者：
Cox, DR
DOI：
10.1161/01.atv.0000222011.13026.25
发表时间：
2006-06-01
影响因子：
8.7
作者：
Kathiresan, Sekar;Yang, Qiong;O'Donnell, Christopher J.
通讯作者：
O'Donnell, Christopher J.
影响因子：
64.8
作者：
Chanock, Stephen J.;Manolio, Teri;Collins, Francis S.
通讯作者：
Collins, Francis S.
影响因子：
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作者：
Fox, Caroline S.;Heard-Costa, Nancy;Atwood, Larry D.
通讯作者：
Atwood, Larry D.