The TAK1-TRAF6 signalling pathway
The TAK1-TRAF6 signalling pathway
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DOI：
10.1016/j.biocel.2009.12.023
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发表时间：
2010-05-01
影响因子：
4
通讯作者：
Landstrom, Marene
中科院分区：
文献类型：
--
作者：
Landstrom, Marene
细胞对病原体、生长因子、细胞因子、细胞外或细胞内应激的反应是细胞适应新的和潜在危险情况的先决条件。如果细胞外或细胞内环境的变化导致DNA损伤或撤销在形态发生期间使用的信号传导途径，则上皮细胞可能被迫经历程序性细胞死亡（凋亡），从而有利于整个生物体或转化为间充质细胞类型（上皮向间充质转化; EMT），以响应特定刺激。综述了目前对稳态、炎症和癌症中信号转导关键组分的认识。少数转录因子是决定特定细胞反应的关键，其中转化生长因子-β（TGF-β）是一个重要的因素，如本文所讨论的。(C)2010爱思唯尔有限公司版权所有。
Cellular responses to pathogens, growth factors, cytokines, extra- or intra-cellular stress, is a prerequisite for the cell to adapt to novel and potentially dangerous situations. If the changes in the extra- or intra-cellular milieu causes DNA-damage or revoke a signalling pathway utilized during morphogenesis, the epithelial cells might be forced to undergo programmed cell death (apoptosis) in the benefit for the whole organism or transform to a mesenchymal cell type (epithelial to mesenchymal transition; EMT), in respond to a specific stimuli. An overview is presented over the current knowledge for the key components in signal transduction in homeostasis, inflammation and cancer. A handful of transcription factors are crucial for the determination of the specific cellular responses, where the transforming growth factor-beta (TGF-beta) is an important factor as discussed in this review. (C) 2010 Elsevier Ltd. All rights reserved.