Detrimental effects of hypercortisolism on brain structure and related risk factors
Detrimental effects of hypercortisolism on brain structure and related risk factors
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DOI：
10.1038/s41598-020-68166-0
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发表时间：
2020-07-29
影响因子：
4.6
通讯作者：
Yu, Yerong
中科院分区：
文献类型：
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作者：
Chen, Yaxi;Zhang, Junhuai;Yu, Yerong
在库欣综合征患者的磁共振成像（MRI）扫描中经常观察到脑结构异常，但其发病机制尚不完全清楚。为了了解活动性库欣病（CD）患者脑结构异常与潜在危险因素之间的关系，共有101例未接受治疗的CD患者和95例性别、年龄和教育程度相匹配的无功能腺瘤（NFA）对照组进行了临床评估和MRI调查，并分析了相关危险因素。对14例经蝶窦手术后持续缓解的患者进行随访。与NFA受试者相比，CD患者的皮质(P
Brain structural abnormalities are often observed on magnetic resonance imaging (MRI) scans of Cushing's syndrome patients, but the pathogenesis is not fully understood. To understand the relationship between brain structural abnormalities and potential risk factors in active Cushing's disease (CD) patients, a total of 101 treatment-naive CD patients and 95 sex-, age- and education matched controls with non-functioning adenomas (NFA) underwent clinical evaluation and MRI investigation, and the relative risk factors were analyzed. 14 patients in sustained remission after transsphenoidal surgery were followed. Compared with the NFA subjects, the patients with CD had more cortical (P