Hippocampal activation of immediate early genes Zenk and c-Fos in zebra finches (Taeniopygia guttata) during learning and recall of a spatial memory task
Hippocampal activation of immediate early genes Zenk and c-Fos in zebra finches (Taeniopygia guttata) during learning and recall of a spatial memory task
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DOI：
10.1016/j.nlm.2009.11.006
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Bischof, Hans-Joachim
中科院分区：
文献类型：
--
作者：
Mayer, Uwe;Watanabe, Shigeru;Bischof, Hans-Joachim
斑胸草雀（Taeniopygia guttata）能够通过在“干水迷宫”中定位空间线索来了解食物的位置。在空间学习过程中，海马体表现出立即早期基因（IEG）Zenk和c-Fos的高表达，表明该区域在学习过程中高度激活。相比之下，如果鸟类不必依赖空间线索，则 IEG 活动几乎不存在。在本实验中，研究了如果回忆所学的空间任务是否也可以观察到海马激活。为此，我们将鸟类在早期学习阶段的海马 Zenk 和 c-Fos 激活与其他已经达到最大表现的鸟类进行了比较。结果表明，鸟类海马体在回忆已学空间任务时也很活跃，但其激活程度明显低于动物实际学习时的激活程度。与之前的实验一样，海马 IEG 表达不仅在神经元活性斑块的位置上表现出强烈的变化，而且在大小和细胞密度上也表现出强烈的变化。观察到的差异有助于这样的观点：即早期基因可能不仅仅是激活的指标，而可能是由于激活和可塑性变化的组合。 (c) 2009 Elsevier Inc. 保留所有权利。
Zebra finches (Taeniopygia guttata) are able to learn the position of food by orienting on spatial cues in a 'dry water maze'. In the course of spatial learning, the hippocampus shows high expression of the immediate early genes (IEGs) Zenk and c-Fos, indicating high activation of this area during learning. In contrast, the IEG activity is nearly absent if the birds do not have to rely on spatial cues. In the present experiment it was investigated whether hippocampal activation can also be observed if the learned spatial task is recalled. For this purpose, the hippocampal Zenk and c-Fos activation of birds in an early learning stage was compared with that of others having well reached their maximal performance. The results show that the avian hippocampus is also active during recall of a learned spatial task, but the activation is significantly lower than in animals learning actually. As in previous experiments, hippocampal IEG expression showed strong variation not only in the position of the active patches of neurons, but also in size and cell density. The observed difference contributes to the view that immediate early genes may not be indicators of activation alone, but may be due to a combination of activation and plastic changes. (c) 2009 Elsevier Inc. All rights reserved.