Stereotyped and specific gene expression programs in human innate immune responses to bacteria
Stereotyped and specific gene expression programs in human innate immune responses to bacteria
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DOI：
10.1073/pnas.231625398
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发表时间：
2002-01-22
影响因子：
11.1
通讯作者：
Relman, DA
中科院分区：
文献类型：
--
作者：
Boldrick, JC;Alizadeh, AA;Relman, DA
先天免疫应答对于防御微生物病原体至关重要。为了研究这种反应的分子编排，我们对人类外周血单核细胞对细菌和细菌产物的反应的基因表达程序进行了系统的检查。我们发现了一个显着的定型程序的基因表达诱导的细菌脂多糖和各种杀死的细菌。这种反应的一个显著特征是，一个精心设计的表达程序专门用于细胞之间的交流。其他特征表明，在细菌感染的背景下，抗原呈递细胞对捕获的抗原的承诺的分子程序。尽管有惊人的相似之处，但对不同细菌的反应存在定性和定量差异。细菌毒力机制对宿主反应程序的调节是不同细菌反应变异的重要来源。
The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found a remarkably stereotyped program of gene expression induced by bacterial lipopolysaccharide and diverse killed bacteria. An intricately choreographed expression program devoted to communication between cells was a prominent feature of the response. Other features suggested a molecular program for commitment of antigen-presenting cells to antigens captured in the context of bacterial infection. Despite the striking similarities, there were qualitative and quantitative differences in the responses to different bacteria. Modulation of this host-response program by bacterial virulence mechanisms was an important source of variation in the response to different bacteria.