ANTERIOR THALAMIC LESIONS AND NEURONAL-ACTIVITY IN THE CINGULATE AND RETROSPLENIAL CORTICES DURING DISCRIMINATIVE AVOIDANCE-BEHAVIOR IN RABBITS
ANTERIOR THALAMIC LESIONS AND NEURONAL-ACTIVITY IN THE CINGULATE AND RETROSPLENIAL CORTICES DURING DISCRIMINATIVE AVOIDANCE-BEHAVIOR IN RABBITS
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DOI：
10.1037/0735-7044.97.5.675
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发表时间：
1983-01-01
影响因子：
1.9
通讯作者：
MAIORCA, RR
中科院分区：
文献类型：
--
作者：
GABRIEL, M;LAMBERT, RW;MAIORCA, RR
12只雄性新西兰大白兔在差异回避条件反射任务中，训练后双侧丘脑前腹侧核的电解性损伤损害了其保持能力(消退和再获得)。此外，在行为习得过程中，损毁取消了在损毁诱导之前在扣带回和脾后皮质发展到听觉CS的兴奋性、辨别性多单位放电。在有损伤的SS中，通过CS诱导的神经元放电减少到低于刺激前基线的水平，兴奋性放电被取代。在训练前对8个SS进行损毁并没有干扰行为获得，但它们确实消除了通常在训练前和训练期间在大脑皮层发生的兴奋性音调诱发的神经元放电。在训练前给予损伤的SS中，CS引起的神经元放电减少在训练开始时没有发生，但在训练过程中出现了这种减少。这些损伤并没有消除前额叶皮质的兴奋性和辨别性神经元活动。结果表明，扣带回和脾后皮质的兴奋性和辨别性神经元放电严重依赖于这些区域与丘脑前核的连接。
Bilateral electrolytic lesions of the anteroventral nucleus of the thalamus given after training impaired retention performance (extinction and reacquisition) of 12 male New Zealand White rabbits in a differential avoidance conditioning task. In addition, the lesions abolished the excitatory, discriminative multiple-unit discharges that had developed in the cingulate and retrosplenial cortices to the auditory CSs during the course of behavioral acquisition, prior to the induction of the lesions. The excitatory discharges were supplanted in the Ss with lesions by CS-elicited reduction of neuronal firing to levels below the prestimulus baseline. Lesions given to 8 Ss before training did not disrupt behavioral acquisition, but they did eliminate the excitatory tone-elicited neuronal discharges that normally occur in the cortex before and during training. The CS-elicited reduction of neuronal firing did not occur at the beginning of training in the Ss given lesions before training, but it developed during the course of training. The lesions did not eliminate the excitatory and discriminative neuronal activity of the prefrontal cortex. Results demonstrate the excitatory and discriminative neuronal discharges in the cingulate and retrosplenial cortices are critically dependent on the connections of these areas with the anterior thalamic nuclei.(26 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)