Prognostic value of cyclin B1 protein expression in colorectal cancer
Prognostic value of cyclin B1 protein expression in colorectal cancer
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DOI：
10.1309/54h4q88a1ubbwpte
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发表时间：
2004-10-01
影响因子：
3.5
通讯作者：
Mueller, W
中科院分区：
文献类型：
--
作者：
Grabsch, H;Lickvers, K;Mueller, W
我们使用免疫组织化学分析研究了细胞周期中G (2)-M相变的关键分子cyclin B1在342例治愈性切除的结直肠癌中的表达及其对预后的影响。269例肿瘤（78.7%）中，超过10%的肿瘤细胞高表达cyclin B1，但cyclin B1表达与肿瘤组织病理特征无相关性。单变量分析显示无病生存和总生存无影响。多因素分析显示，pT和pN类别、外血管侵犯和低级别肿瘤细胞分化是总生存的独立预后预测因素，pT和pN类别和肿瘤部位是无病生存的独立预后预测因素。根据我们的研究结果，细胞周期蛋白B1的高表达在结直肠癌中是一个频繁和早期的事件。然而，细胞周期蛋白B1的表达既不是结直肠癌患者预后的预测因子，也不是确定疾病复发风险较高的患者亚组的合适工具。
We used immunohistochemical analysis to study the expression and prognostic impact of cyclin B1, a key molecule for G (2)-M phase transition during the cell cycle, in a series of 342 curatively resected colorectal carcinomas.In 269 tumors (78.7%), high expression of cyclin B1 in more than 10% of tumor cells was observed, but there was no association between cyclin B1 expression and histopathologic tumor features. Univariate analysis revealed no impact on disease-free and overall survival. Multivariate analysis revealed pT and pN categories, extramural blood vessel invasion, and low-grade tumor cell differentiation as independent prognostic predictors for overall survival, and pT and pN categories and tumor site for disease-free survival.According to our results, high expression of cyclin B1 is a frequent and early event in colorectal carcinomas. However, cyclin B1 expression is neither a predictor of prognosis in patients with colorectal cancer nor a suitable tool for identifying subgroups of patients at higher risk for disease recurrence.