Differential effects of acetylcholine in the chicken auditory neostriatum and hyperstriatum ventrale — studies in vivo and in vitro
Differential effects of acetylcholine in the chicken auditory neostriatum and hyperstriatum ventrale — studies in vivo and in vitro
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乙酰胆碱对鸡听觉新纹状体和上纹状体腹侧的不同作用——体内和体外研究
DOI：
10.1007/bf00610227
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
C. Müller
中科院分区：
文献类型：
--
作者：
C. Müller
1.在清醒鸡和体外脑片上研究了乙酰胆碱(ACh)对尾侧听性端脑单个单位反应的影响。2.观察到对ACh反应的两种类型的电生理行为：一种是听觉上纹状体腹侧大多数神经元典型的细胞放电抑制，另一种是以新纹状体听觉单位为主的神经元反应的易化。3.ACh的易化作用也存在于超纹状体细胞，但通常以间接抑制为主。4.在清醒的鸟类中，可以通过施加潜在的唤醒感觉刺激来模拟ACh对单单位反应的易化作用。5.乙酰胆碱的作用可被M受体阻断剂东莨菪碱所拮抗。6.抑制性反应也可被GABA拮抗剂荷包牡丹碱所拮抗，这可归因于ACh对GABA能抑制中间神经元的激活。有证据表明，易化反应是电压依赖性钾通道关闭的结果。7.讨论了胆碱能传入在端脑听觉信息处理中的可能作用，并与哺乳动物新皮质的胆碱能影响进行了比较。
1. The effect of acetylcholine (ACh) on the response properties of single units in the caudal auditory telencephalon was studied both in awake chickens and in an in vitro slice preparation. 2. Two types of electrophysiological behavior in response to ACh were observed: an inhibition of cell firing typical for the majority of neurons in the auditory hyperstriatum ventrale and a facilitation of neuronal responses seen predominantly in neostriatal auditory units. 3. The facilitatory effect of ACh is also present in hyperstriatal cells, but is usually dominated by an indirect inhibition. 4. ACh-induced facilitation on single unit responses could be mimicked in awake birds by applying potentially arousing sensory stimuli. 5. The effects of ACh are antagonized by the muscarinic receptor blocker scopolamine. 6. Inhibitory responses can also be antagonized by the GABA-antagonist bicuculline and thus can be attributed to an ACh-induced activation of GABAergic inhibitory interneurons. Evidence is given that the facilitatory responses result from a closure of voltage-dependent potassium channels. 7. The results are discussed with respect to a possible role of cholinergic afferents in telencephalic processing of auditory information and in comparison with the cholinergic influences in the mammalian neocortex.