Seroprevalence of Powassan Virus in New England Deer, 1979-2010
Seroprevalence of Powassan Virus in New England Deer, 1979-2010
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DOI：
10.4269/ajtmh.12-0586
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发表时间：
2013-06-01
影响因子：
3.3
通讯作者：
Magnarelli, Louis A.
中科院分区：
文献类型：
--
作者：
Nofchissey, Robert A.;Deardorff, Eleanor R.;Magnarelli, Louis A.
鲍瓦桑病毒及其亚型鹿虱病毒是在北美流行的扁虱传播的黄病毒。近年来，由这些病原体感染人类的发病率似乎有所上升。为了确定白尾鹿的暴露模式，白尾鹿是经常被扁虱寄生的潜在有用的哨兵，我们使用一种新的重组鹿虱病毒-西尼罗河病毒嵌合病毒对1979-2010年在康涅狄格州、缅因州和佛蒙特州收集的血清样本进行中和抗体筛选。在所有三个州都检测到了接触的证据。总体而言，我们的结果表明，血清阳性率在时间和空间上是可变的，这表明接触鲍瓦桑病毒的风险也是同样可变的。
Powassan virus and its subtype, deer tick virus, are closely related tick-borne flaviviruses that circulate in North America. The incidence of human infection by these agents appears to have increased in recent years. To define exposure patterns among white-tailed deer, potentially useful sentinels that are frequently parasitized by ticks, we screened serum samples collected during 1979-2010 in Connecticut, Maine, and Vermont for neutralizing antibody by using a novel recombinant deer tick virus-West Nile virus chimeric virus. Evidence of exposure was detected in all three states. Overall our results demonstrate that seroprevalence is variable in time and space, suggesting that risk of exposure to Powassan virus is similarly variable.