Protective Efficacy of Commercial Newcastle Disease Vaccines Against Challenge of Goose Origin Virulent Newcastle Disease Virus in Geese
Protective Efficacy of Commercial Newcastle Disease Vaccines Against Challenge of Goose Origin Virulent Newcastle Disease Virus in Geese
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DOI：
10.1637/8239-013008-reg.1
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发表时间：
2008-09-01
期刊：
影响因子：
1.4
通讯作者：
Li, Wenliang
中科院分区：
文献类型：
--
作者：
Dai, Yabin;Liu, Mei;Li, Wenliang
1997年以来，新城疫(ND)在中国多地暴发，造成了鹅的高发病率和高死亡率，给养殖户造成了巨大的经济损失，但中国目前尚无获得许可的、特异的疫苗。用La Sota疫苗、Mukteswar疫苗、禽流感和新城疫重组活疫苗(RL-H5株)和新城疫油乳剂灭活疫苗(La Sota株)等不同组合和不同剂量免疫雏鹅。根据抗体应答水平和对鹅源新城疫强毒株的保护程度来评估保护效果。结果表明，两剂La Sota疫苗(即比鸡多一剂)免疫，2~3周后再接种2~5剂Mukteswar疫苗，不仅可诱导较高的HI抗体水平，而且可产生较持久的保护作用。该免疫程序可用于鹅新城疫的预防。
Since 1997, severe outbreaks of Newcastle disease (ND) in geese in many regions throughout China have resulted in high morbidity and mortality, and great economic loss to farmers; however, no licensed, specific vaccine is yet available for this disease in China. In this study, goslings were immunized with different combinations and dosages of several commercial ND vaccines including La Sota vaccine, Mukteswar vaccine, recombinant live vaccine against avian influenza (AI) and ND (rL-H5 strain), and inactivated ND oil-emulsion vaccine (La Sota strain). The protective effects were evaluated based upon the level of antibody response and the degree of protection against the goose-origin virulent NDV strain. The result showed that two doses (i.e., one more than that for chicken) of La Sota vaccine priming, followed by 2-5 doses of Mukteswar vaccine boosting 2-3 weeks later, not only induced higher HI antibody levels, but also conferred longer-lasting protection. This immunization procedure can be recommended for prevention of ND in geese.