Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer.
Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer.
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DOI：
10.1371/journal.pone.0034392
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Vachani A
中科院分区：
文献类型：
--
作者：
Kossenkov AV;Dawany N;Evans TL;Kucharczuk JC;Albelda SM;Showe LC;Showe MK;Vachani A
非小细胞肺癌（NSCLC）患者癌症复发的预测目前依赖于对包括年龄、肿瘤分期和吸烟史在内的临床特征的评估。需要更好地预测具有较差生存率的早期癌症患者和具有较好生存率的晚期患者，以设计患者定制的治疗方案。我们分析了NSCLC患者外周血单个核细胞（PBMC）RNA中的基因表达，以确定预测患者总体生存率的特征。我们发现NSCLC患者的PBMC基因表达模式与肿瘤的模式一样，具有预测患者预后的信息。我们确定并验证了一个26个基因的预后面板，是独立的临床分期。许多其他预后基因对髓系细胞具有特异性，并且在生存期较短的患者中表达更高。我们还观察到肿瘤切除后收集的PBMC中显著数量的预后基因改变表达水平。这些术后基因表达谱可能提供一种重新评估预后的方法。这些研究进一步表明，患者的预后不仅取决于肿瘤基因表达谱，还可能受到外周免疫细胞中反映的免疫应答的影响。
Prediction of cancer recurrence in patients with non-small cell lung cancer (NSCLC) currently relies on the assessment of clinical characteristics including age, tumor stage, and smoking history. A better prediction of early stage cancer patients with poorer survival and late stage patients with better survival is needed to design patient-tailored treatment protocols. We analyzed gene expression in RNA from peripheral blood mononuclear cells (PBMC) of NSCLC patients to identify signatures predictive of overall patient survival. We find that PBMC gene expression patterns from NSCLC patients, like patterns from tumors, have information predictive of patient outcomes. We identify and validate a 26 gene prognostic panel that is independent of clinical stage. Many additional prognostic genes are specific to myeloid cells and are more highly expressed in patients with shorter survival. We also observe that significant numbers of prognostic genes change expression levels in PBMC collected after tumor resection. These post-surgery gene expression profiles may provide a means to re-evaluate prognosis over time. These studies further suggest that patient outcomes are not solely determined by tumor gene expression profiles but can also be influenced by the immune response as reflected in peripheral immune cells.
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影响因子：
120.7
作者：
Jemal, A;Ward, E;Thun, M
通讯作者：
Thun, M
血浆 microRNA 作为非小细胞肺癌的潜在生物标志物
DOI：
10.1038/labinvest.2010.194
发表时间：
2011-04
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.8
作者：
Stachon, A;Böning, A;Krieg, M
通讯作者：
Krieg, M
影响因子：
14.9
作者：
Huang, Da Wei;Sherman, Brad T.;Lempicki, Richard A.
通讯作者：
Lempicki, Richard A.
影响因子：
3.7
作者：
Abbas AR;Wolslegel K;Seshasayee D;Modrusan Z;Clark HF
通讯作者：
Clark HF