Choroidal thickness and axial length changes in myopic children treated with orthokeratology
Choroidal thickness and axial length changes in myopic children treated with orthokeratology
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DOI：
10.1016/j.clae.2017.09.010
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发表时间：
2017-12-01
影响因子：
3.2
通讯作者：
Yang, Xiao
中科院分区：
文献类型：
--
作者：
Li, Zhouyue;Cui, Dongmei;Yang, Xiao
目的：目的：分析近视儿童角膜塑形镜（Orthokeratology，Ortho-k）治疗前后中心凹下脉络膜厚度（sub-fovealchoroidalthickness，SFChT）的变化及其与眼轴长度（axiallength，AL）变化的关系。SFChT和眼生物特征，包括AL，分别在基线，1个月，6个月后，在两组透镜wear.Results：AL显着增加，在两组随着时间的推移。在Ortho-k组中，SFChT也增加;然而，对照组中SFChT随时间推移无显著变化。在6个月随访时，角膜塑形镜组的眼球生长幅度显著低于对照组（0.06 +/-0.10 mm vs. 0.17 +/-0.10 mm，P <0.001）。在1个月和6个月随访时，Ortho-k角膜塑形术组的SFChT显著厚于对照组（15.78 +/-11.37 μ m vs. -2.98 +/-8.96 μ m，P <0.001（1个月随访）; 21.03 +/-12.74 μ m vs. - 2.50+/-14.43 μ m，P <0.001（6个月随访）），尽管两次随访之间没有显著差异（角膜塑形镜组P = 0.102;对照组P = 0.898）。大脉络膜血管层（LCVL）的变化占大多数的中心凹下脉络膜增厚（约77%和80%，在一个月和六个月的访问，分别）。结论：角膜塑形术治疗引起显着的脉络膜增厚和眼睛生长的减缓。LCVL增厚占SFChT增厚的大部分。然而，其在近视控制中的潜在机制需要进一步研究。
Purpose: To analyze the change in subfoveal choroidal thickness (SFChT) and its relationship with changes in axial length (AL) in myopic children treated with Orthokeratology (Ortho-k).Methods: Fifty myopic children participated in this study: 29 subjects were treated with Ortho-k lenses and 21 with single vision distance spectacles. The SFChT and ocular biometrics, including AL, were measured at baseline, one month, and six months after lens wear in both groups.Results: AL significantly increased in both groups over time. In the Ortho-k group, SFChT also increased; however, there was no significant change in SFChT in the control group over time. At the six-month visit, the magnitude of eye growth was significantly reduced in the Ortho-k group compared to the control group (0.06 +/- 0.10 mm vs. 0.17 +/- 0.10 mm, P < 0.001). SFChT was significantly thicker in the Ortho-k group compared to the control group at the one-month and six-month visits (15.78 +/- 11.37 mu m vs. -2.98 +/- 8.96 mu m, P < 0.001 (one-month visit); 21.03 +/- 12.74 mu m vs.-2.50 +/- 14.43 mu m, P < 0.001 (sixmonth visit)), although there was no significant difference between the two follow-up visits (P= 0.102 for the Ortho-k group; P = 0.898 for the control group). Changes in the large choroidal vascular layer (LCVL) accounted for the majority of subfoveal choroidal thickening (approximately 77% and 80% at one-month and six-month visits, respectively).Conclusion: Ortho-k treatment induced significant choroidal thickening and a slowing of eye growth. LCVL thickening accounted for the majority of SFChT thickening. However, its potential mechanism in myopia control requires further investigation.