ENO1 and Cancer.
ENO1 and Cancer.
复制标题
ENO1与癌症
DOI：
10.1016/j.omto.2021.12.026
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发表时间：
2022-03-17
期刊：
影响因子：
--
通讯作者：
Ping Y
中科院分区：
文献类型：
--
作者：
Huang CK;Sun Y;Lv L;Ping Y
α-烯醇化酶（ENO 1），也称为2-磷酸-D-甘油酸水解酶，是一种糖酵解酶，在糖酵解过程中催化2-磷酸甘油酸转化为磷酸烯醇化酸。它是一种多功能癌蛋白，存在于细胞表面和细胞质中，有助于击中十个“癌症标志”中的七个。ENO 1的糖酵解功能使细胞能量失调，维持肿瘤增殖，并抑制癌细胞凋亡。此外，ENO 1逃避生长抑制因子，并帮助肿瘤避免免疫破坏。此外，ENO 1在细胞表面“月光”，并作为纤溶酶原受体，通过诱导血管生成促进癌症侵袭和转移。ENO 1在多种癌症类型上的过表达及其在肿瘤表面上的定位使其成为一种很好的预后和诊断癌症生物标志物以及可获得的肿瘤治疗靶点。本文综述了ENO 1与癌症关系的最新研究进展，探讨了ENO 1作为癌症生物标志物的潜力，并讨论了ENO 1在新型肿瘤免疫治疗策略中的作用。Ping及其同事回顾了ENO 1与多种癌症类型之间的关系，评估了ENO 1在肿瘤发展中的潜在作用，并更新了ENO 1靶向肿瘤治疗的最新进展。
α-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit seven out of ten “hallmarks of cancer.” ENO1's glycolytic function deregulates cellular energetic, sustains tumor proliferation, and inhibits cancer cell apoptosis. Moreover, ENO1 evades growth suppressors and helps tumors to avoid immune destruction. Besides, ENO1 “moonlights” on the cell surface and acts as a plasminogen receptor, promoting cancer invasion and metastasis by inducing angiogenesis. Overexpression of ENO1 on a myriad of cancer types together with its localization on the tumor surface makes it a great prognostic and diagnostic cancer biomarker as well as an accessible oncotherapeutic target. This review summarizes the up-to-date knowledge about the relationship between ENO1 and cancer, examines ENO1's potential as a cancer biomarker, and discusses ENO1's role in novel onco-immunotherapeutic strategies. Ping and colleagues review the relationship between ENO1 and multiple cancer types, evaluate ENO1's potential role in tumor development, and update recent advancements in ENO1-targeted onco-therapies.
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