[Research advances on multifunctional hydrogel dressings for treatment of diabetic chronic wounds].
[Research advances on multifunctional hydrogel dressings for treatment of diabetic chronic wounds].
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DOI：
10.3760/cma.j.cn501120-20210715-00249
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发表时间：
2021-11-20
影响因子：
--
通讯作者：
Gao, C Y
中科院分区：
文献类型：
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作者：
Cao, W B;Gao, C Y
糖尿病可导致多种并发症，如慢性创面（糖尿病足），是糖尿病患者死亡的重要原因之一。高血糖、高水平的氧化应激和炎症以及对感染的易感性等不利因素导致糖尿病慢性伤口难以愈合甚至恶化。由于水凝胶具有含水量高、生物相容性好、理化性质可调等优点，已成为创伤敷料研究的热点。与纱布等传统敷料相比，水凝胶敷料可以提供有利于伤口愈合的湿润环境。通过生物活性成分的负载和水凝胶组成和结构的调节，可赋予水凝胶敷料优异的组织粘附性、抗菌能力、抗氧化和炎症调节作用等，因此在伤口敷料应用中显示出巨大的前景。本文从水凝胶材料的特点和糖尿病慢性创面微环境的特点出发，综述了近年来新型多功能水凝胶敷料在糖尿病慢性创面治疗中的研究进展，并对目前水凝胶敷料的不足进行了讨论，提出了展望。
Diabetes can lead to a variety of complications, such as chronic wound (diabetic foot), which is one of the important causes of death for patients with diabetes. Unfavorable factors such as high blood glucose, high level of oxidative stress and inflammation, and susceptibility to infection lead to difficult healing and even worsening of diabetic chronic wounds. Due to the advantages of high water content, good biocompatibility, and tunable physicochemical properties, the hydrogels have become hot-spot materials in wound dressing research. Compared with the traditional dressings such as gauze, the hydrogel dressings can provide a moist environment that is beneficial for wound healing. By loading of bioactive components and modulation of compositions and structures of hydrogels, the hydrogel dressings can be endowed with excellent tissue adhesion, antibacterial ability, anti-oxidation, and inflammation regulation effect, etc., and thus show great prospects in wound dressing applications. Based on the characteristics of hydrogel materials and microenvironment of diabetic chronic wound, this review summarized the research advances on new multifunctional hydrogel dressings for the treatment of diabetic chronic wounds in recent years, and discussed the drawbacks of current hydrogel dressings with prospects proposed.