Infection Risk for Persons Exposed to Highly Pathogenic Avian Influenza A H5 Virus-Infected Birds, United States, December 2014-March 2015.
Infection Risk for Persons Exposed to Highly Pathogenic Avian Influenza A H5 Virus-Infected Birds, United States, December 2014-March 2015.
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DOI：
10.3201/eid2112.150904
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发表时间：
2015-12
影响因子：
11.8
通讯作者：
H5 Investigation Group
中科院分区：
文献类型：
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作者：
Arriola CS;Nelson DI;Deliberto TJ;Blanton L;Kniss K;Levine MZ;Trock SC;Finelli L;Jhung MA;H5 Investigation Group
超过 100 名暴露者中尚未报告感染，表明动物向人类传播的风险较低。新出现的高致病性禽流感 (HPAI) A H5 病毒已在美国鸟类中引起疫情爆发。这些病毒在基因上与以前引起人类疾病（尤其是在亚洲和非洲）的 HPAI H5 病毒不同。为了评估美国 HPAI H5 病毒从动物到人的传播风险，我们确定了 2014 年 12 月 15 日至 2015 年 3 月 31 日期间每次爆发期间自我报告接触受感染鸟类的人数、接触后 10 天期间患有急性呼吸道感染 (ARI) 的人数，以及通过实时逆转录 PCR 或血清学检测检测出流感阳性的 ARI 人数。在 60 次爆发期间在13个州，共有164人接触过受感染的鸟类。其中 5 人在接触后 10 天内出现急性呼吸道感染 (ARI)。在任何 ARI 患者中均未发现 H5 流感病毒感染，这表明动物向人类传播 HPAI H5 病毒的风险较低。
No infections have been reported among >100 exposed persons, suggesting a low risk for animal-to-human transmission. Newly emerged highly pathogenic avian influenza (HPAI) A H5 viruses have caused outbreaks among birds in the United States. These viruses differ genetically from HPAI H5 viruses that previously caused human illness, most notably in Asia and Africa. To assess the risk for animal-to-human HPAI H5 virus transmission in the United States, we determined the number of persons with self-reported exposure to infected birds, the number with an acute respiratory infection (ARI) during a 10-day postexposure period, and the number with ARI who tested positive for influenza by real-time reverse transcription PCR or serologic testing for each outbreak during December 15, 2014–March 31, 2015. During 60 outbreaks in 13 states, a total of 164 persons were exposed to infected birds. ARI developed in 5 of these persons within 10 days of exposure. H5 influenza virus infection was not identified in any persons with ARI, suggesting a low risk for animal-to-human HPAI H5 virus transmission.