Synthesis and assay of isoquinoline derivatives as HIV-1 Tat-TAR interaction inhibitors
Synthesis and assay of isoquinoline derivatives as HIV-1 Tat-TAR interaction inhibitors
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DOI：
10.1016/j.bmcl.2005.01.068
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发表时间：
2005-09-01
影响因子：
2.7
通讯作者：
Yang, M
中科院分区：
文献类型：
--
作者：
He, MZ;Yuan, DK;Yang, M
以HIV-1 TAR元件为靶点，合成了4个新的异喹啉衍生物。它们结合TAR RNA和抑制Tat-TAR RNA相互作用的能力通过CE分析、Tat依赖性HIV-1 LTR驱动的CAT测定和SIV诱导的合胞体评价来确定。(c)2005爱思唯尔有限公司保留所有权利。
Four new isoquinoline derivatives bearing guanidiniurn group or amino group-terminated side chain were synthesized to target the HIV-1 TAR element. Their abilities to bind TAR RNA and inhibit Tat-TAR RNA interaction were determined by CE analysis, a Tat-dependent HIV-1 LTR-driven CAT assay and SIV-induced syncytium evaluation. (c) 2005 Elsevier Ltd. All rights reserved.