A Series of 35 Cutaneous Infections Caused by Mycobacterium marinum in Han Chinese Population
A Series of 35 Cutaneous Infections Caused by Mycobacterium marinum in Han Chinese Population
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DOI：
10.1155/2023/5514275
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发表时间：
2023-08-16
影响因子：
2.2
通讯作者：
Zhang，Furen
中科院分区：
文献类型：
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作者：
Chen，Wenjie;Bao，Fangfang;Zhang，Furen
皮肤海洋分枝杆菌感染是一种传染性越来越强的疾病，提出了独特的诊断和治疗挑战。本研究的目的是评价不同类型皮肤病变患者接受单药或多药治疗的至治疗时间差异。此外，还对M.并探讨了宿主免疫应答的机制。对35例M.海水养殖感染的研究进展。分析其临床特征、组织病理学和实验室数据以及治疗结果。免疫组化分析阐明M. 9例患者和5例健康对照者均存在海水感染。在35例患者中，25例（71.4%）有孢子虫样病变。孢子虫样病变或多种药物治疗的患者持续时间较长，尽管差异不显著，可能是由于队列较小。然而，这一趋势在以往的研究中也被观察到，值得进一步关注。患者标本中细胞因子（IFN-γ、IL-4、IL-9和FOXP 3）的表达水平显著上调，而患者组和对照组之间IL-17和IL-22的表达水平无显著差异。
CutaneousMycobacterium marinuminfection is an increasingly infectious disease presenting unique diagnostic and therapeutic challenges. The aim of this study was to evaluate the differences in time to treatment among patients with different types of skin lesions and who were treated with single or multidrug therapies. In addition, the clinical characteristics ofM. marinuminfection were explored and the mechanism of the host immune responses was investigated. The electronic medical records of 35 patients withM. marinuminfection were reviewed. The clinical characteristics, histopathological and laboratory data, and treatment outcomes were analyzed. Immunohistochemical analysis was performed to clarify the immune mechanisms induced byM. marinuminfection in 9 patients and 5 healthy controls. Of the 35 patients, 25 (71.4%) had lesions with sporotrichoid patterns. The duration of patients with sporotrichoid lesions or treatment with multiple drugs was longer, although differences were not significant, possibly due to the small cohort. However, this trend was also observed in previous studies, making it worthy of further attention. Expression levels of cytokines (IFN‐γ, IL‐4, IL‐9, and FOXP3) were significantly upregulated in the patient specimens, whereas there were no significant differences in IL‐17 and IL‐22 expression levels between the patient and control groups.