Low HDL and high triglycerides predict COVID-19 severity.
Low HDL and high triglycerides predict COVID-19 severity.
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DOI：
10.1038/s41598-021-86747-5
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发表时间：
2021-03-30
影响因子：
4.6
通讯作者：
STACOV-XULA research group
中科院分区：
文献类型：
--
作者：
Masana L;Correig E;Ibarretxe D;Anoro E;Arroyo JA;Jericó C;Guerrero C;Miret M;Näf S;Pardo A;Perea V;Pérez-Bernalte R;Plana N;Ramírez-Montesinos R;Royuela M;Soler C;Urquizu-Padilla M;Zamora A;Pedro-Botet J;STACOV-XULA research group
脂质在SARS-CoV-2感染过程中不可或缺。尚未严格评估COVID-19期间血脂谱的临床意义。我们的目的是确定血脂谱与SARS-CoV-2感染的临床演变。观察性横断面研究，包括1411例住院的COVID-19患者，在住院前（n：1305）或住院期间（n：297）有可用的标准血脂谱。分析了血清总胆固醇、LDL、非HDL和HDL胆固醇对预测COVID-19预后（重度vs轻度）的有用性。患有严重COVID-19演变的患者在感染前具有较低的HDL胆固醇和较高的甘油三酯水平。在住院期间测量的血脂谱也显示，严重的结果与较低的HDL胆固醇水平和较高的甘油三酯相关。HDL胆固醇和甘油三酯浓度与铁蛋白和D-二聚体水平相关，但与CRP水平无关。感染期间存在致动脉粥样硬化性血脂异常与COVID-19感染预后恶化密切相关。住院前或住院期间测得的低HDL胆固醇和高甘油三酯浓度是严重病程的强预测因子。血脂谱应被视为炎症的敏感标志物，并应在COVID-19患者中进行测量。
Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
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DOI：
10.1093/ehjcvp/pvaa128
发表时间：
2022-02-16
影响因子：
7.1
作者：
Masana, Lluis;Correig, Eudald;Pedro-Botet, Juan
通讯作者：
Pedro-Botet, Juan
影响因子：
--
作者：
Saballs, M.;Parra, S.;Castro, A.
通讯作者：
Castro, A.
影响因子：
3.8
作者：
TengkuMuhammad, TS;Hughes, TR;Ramji, DP
通讯作者：
Ramji, DP
DOI：
10.1164/rccm.201806-1157oc
发表时间：
2019-04-01
影响因子：
24.7
作者：
Trinder, Mark;Genga, Kelly R.;Brunham, Liam R.
通讯作者：
Brunham, Liam R.
影响因子：
11.8
作者：
Barcia, AM;Harris, HW
通讯作者：
Harris, HW