Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer
Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer
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DOI：
10.1006/jmrb.1996.0104
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发表时间：
1996-07-01
期刊：
影响因子：
--
通讯作者：
Glickson, JD
中科院分区：
文献类型：
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作者：
He, QH;Bhujwalla, ZM;Glickson, JD
描述了SEL-MQC脉冲序列的扩展-SEE-SEL-MQC(自旋-回声增强的选择性多量子相干转移)-在单次扫描中完全抑制含有流动脂质的组织中的脂和水，并检测多个代谢物的H-1共振。如在Sel-MQC乳酸编辑实验中[Q.He等，J.Magn。雷森。B106,203(1995)]，See-SelMQC从其ZQ-->；DQ相干转移途径获得乳酸；此外，该方法通过使用额外的频率选择性脉冲和梯度，通过选择性地产生额外的自旋回波来恢复来自其他代谢物的信号，该方法引入的乳酸信号强度不会损失超过50%的损失，通过多量子相干转移过程，胆碱和乳酸的空间分布与体模和体内，在皮下移植的小鼠EMT6肿瘤中，已被同时绘制。(C)1996年学术出版社。
An extension of the Sel-MQC pulse sequence-SEE-SelMQC (spin-echo-enhanced selective multiple-quantum coherence transfer)-that completely suppresses lipid and water in tissues containing mobile lipid in a single scan and detects H-1 resonances of multiple metabolites is described. As in the Sel-MQC lactate-editing experiments [Q. He et al., J. Magn. Reson. B 106, 203 (1995)], SEE-SelMQC acquires lactate from its ZQ --> DQ coherence-transfer pathway; in addition, the method recovers signal from other metabolites by selective generation of additional spin echoes using extra frequency-selective pulses and gradients, This method introduces no loss of lactate signal intensity beyond the 50% that is lost through the multiple-quantum coherence-transfer process, The spatial distributions of choline and lactate with a phantom and in vivo, in subcutaneously implanted murine EMT6 tumors, have been simultaneously mapped. (C) 1996 Academic Press, Inc.