Relative contributions of cardiorespiratory fitness and visceral fat to metabolic syndrome in patients with diabetes mellitus.
Relative contributions of cardiorespiratory fitness and visceral fat to metabolic syndrome in patients with diabetes mellitus.
复制标题
心肺健康和内脏脂肪对糖尿病患者代谢综合征的相对贡献。
DOI：
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发表时间：
2005
影响因子：
2.1
通讯作者：
H. Sasaki
中科院分区：
文献类型：
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作者：
S. Kumagai;Y. Kai;M. Nagano;Buhao Zou;H. Kishimoto;H. Sasaki
本研究的目的是研究耐力健身和内脏脂肪堆积对日本男性糖耐量受损（IGT）或2型糖尿病（DM）患者代谢综合征患病率的影响。这项横断面研究的受试者包括135名日本男性IGT或2型糖尿病患者，他们没有服用任何药物或干预。根据使用自行车测力计的Astrand列线图预测的最大摄氧量（[公式：见正文] O（2）max）的三分位数，将他们分为三个健身类别（低、中、高）。代谢综合征的定义基于WHO标准。使用计算机断层扫描确定内脏脂肪面积（VFA）。与高体能类别的受试者相比，低体能类别受试者的年龄和VFA校正比值比为3.49（95% CI，1.13-10.82）。我们根据三个VFA和三个[公式：见正文]（2）最大水平计算了9个类别中代谢综合征患病率的比值比。在中等和低[公式：见正文]（2）最大值类别中，比值比随VFA水平的升高而升高。在低健身和高内脏脂肪组中观察到最高的比值比。在高[公式：见正文] O（2）max类别中，在中等和高VFA类别中未观察到显著优势比。这些结果表明，在日本男性IGT和2型糖尿病患者中，高程度的心肺适应性有助于降低代谢综合征的患病率。
The objective of this study was to examine the contribution of endurance fitness and visceral fat accumulation on the prevalence of metabolic syndrome in Japanese male patients with either an impaired glucose tolerance (IGT) or type 2 diabetes mellitus (DM). The subjects of this cross-sectional study consisted of 135 Japanese male patients with either IGT or type 2 DM who had not taken any medication or intervention. They were classified into three fitness categories (low, moderate, and high) based on the tertiles of their maximal oxygen uptake ( [Formula: see text] O(2)max) predicted by the Astrand nomogram using a cycle ergometer. Metabolic syndrome was defined based on the WHO criteria. The visceral fat area (VFA) was determined using a computed tomography scan. The age- and VFA-adjusted odds ratio was 3.49 (95% CI, 1.13-10.82) for subjects in the low fitness category in comparison to those in the high fitness category. We calculated the odds ratio for the prevalence of metabolic syndrome in the nine categories classified based on the three VFA and three [Formula: see text] (2)max levels. In Moderate- and Low- [Formula: see text] (2) max categories, the odds ratios increased in line with increases in the VFA level. The highest odds ratios were observed in the low fitness and high visceral fat group. In the High- [Formula: see text] O(2)max category, no significant odds ratios were observed in the Moderate- and High-VFA categories. These results indicate that a high degree of cardiorespiratory fitness positively contributed to the low prevalence of metabolic syndrome in Japanese male patients with IGT and type 2 DM.