Vasicine alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis and passive cutaneous anaphylaxis in BALB/c mice
Vasicine alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis and passive cutaneous anaphylaxis in BALB/c mice
复制标题
DOI：
10.1016/j.clim.2022.109102
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Feng Huang
中科院分区：
文献类型：
--
作者：
Yi Zhang;Wenxia Du;Defen Zhu;Meiling Li;Lu Qu;Gaoxiong Rao;Yuping Lin;Xiaoyun Tong;Yun Sun;Feng Huang
Atopic dermatitis (AD), a type of skin inflammation, is associated with immune response mediated by T-helper 2 (Th2) cells, and mast cells. Vasicine is an alkaloid isolated from Adhatoda vasica , a popular Ayurvedic herbal medicine used for treating inflammatory conditions. In the present study, the anti-AD effects of vasicine were evaluated on 2,4-dinitrochlorobenzene-induced AD-like skin lesions in BALB/c mice. The potential anti-allergic effects of vasicine were also assessed using the passive cutaneous anaphylaxis (PCA) test. The results showed that the oral administration of vasicine improved the severity of AD-like lesional skin by decreasing histopathological changes and restoring epidermal thickness. Vasicine also inhibited the infiltration of mast cells in the skin and reduced the levels of pro-Th2 and Th2 cytokines as well as immunoglobulin E in the serum. Finally, vasicine inhibited the expression of pro-Th2 and Th2 cytokines in skin tissues, indicating the therapeutic potential of vasicine for AD. • Vasicine alleviated atopic dermatitis-like symptoms in BALB/c mice. • Vasicine inhibited the infiltration of mast cell in skin and the passive cutaneous anaphylaxis (PCA) test. • Vasicine inhibited the pro-Th2 and Th2 cytokines in serum and in skin tissue. • Vasicine is an immunity supplements with potential anti-allergic properties.
