Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer.
Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer.
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DOI：
10.1109/tuffc.2015.007113
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Konofagou EE
中科院分区：
文献类型：
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作者：
Chen H;Hou GY;Han Y;Payen T;Palermo CF;Olive KP;Konofagou EE
简谐运动成像(HMI)是一种基于辐射力的弹性成像技术，它跟踪正弦超声辐射力引起的组织振荡位移，以评估相对组织刚度。本研究的目的是评价HMI在胰腺肿瘤检测和高强度聚焦超声(HIFU)治疗监测中的可行性。HMI系统由聚焦超声换能器和诊断超声换能器组成，前者产生正弦辐射力以诱导50赫兹的组织振荡运动，后者基于采集的射频信号使用一维互相关算法检测轴向组织位移。对于胰腺肿瘤的检测，对转基因小鼠的胰腺肿瘤和野生型小鼠的正常胰腺生成HMI图像。所获得的HMI图像显示正常胰腺和恶性胰腺之间的高对比度，平均峰/峰位移比为3.2。组织学分析表明，当HMI仅用于弹性成像时，与组织损伤无关。在胰腺肿瘤消融监测中，聚焦超声换能器的声功率和脉冲长度均高于肿瘤检测超声换能器，可同时诱导HIFU热消融和组织振荡位移，从而在不中断肿瘤消融的情况下实现HMI监测。HIFU消融HMI监测发现，HIFU消融前后HMI峰间位移均有明显下降，降幅在15.8%~57.0%之间。组织学分析证实了HIFU照射后热损伤的形成。本研究论证了HMI在腹部肿瘤检测和HIFU消融监测中的可行性。
Harmonic motion imaging (HMI) is a radiation force-based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess relative tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radiofrequency signals using a 1D cross-correlation algorithm. For pancreatic tumor detection, HMI images were generated for pancreatic tumors in transgenic mice and normal pancreases in wild-type mice. The obtained HMI images showed a high contrast between normal and malignant pancreases with an average peak-to-peak HMI displacement ratio of 3.2. Histological analysis showed that no tissue damage was associated with HMI when it was used for the sole purpose of elasticity imaging. For pancreatic tumor ablation monitoring, the focused ultrasound transducer was operated with a higher acoustic power and longer pulse length than that used in tumor detection to simultaneously induce HIFU thermal ablation and oscillatory tissue displacements, allowing HMI monitoring without interrupting tumor ablation. HMI monitoring of HIFU ablation found significant decreases in the peak-to-peak HMI displacements before and after HIFU ablation with a reduction rate ranging from 15.8% to 57.0%. The formation of thermal lesions after HIFU exposure was confirmed by histological analysis. This study demonstrated the feasibility of HMI in abdominal tumor detection and HIFU ablation monitoring.