Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China
Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China
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DOI：
10.1007/s11356-014-3970-9
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发表时间：
2015-05-01
影响因子：
5.8
通讯作者：
Wang, Luhua
中科院分区：
文献类型：
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作者：
Ding, Xiao;Jiang, Meng;Wang, Luhua
实验和流行病学研究表明，血清微量元素水平可能与乳腺癌的风险。我们比较了来自中国山东的乳腺癌患者和正常对照者的15种微量元素的血清水平，以评估血清微量元素水平是否与乳腺癌风险相关。88名乳腺癌患者和84名健康对照者参加了这项研究。采用Spectraspan V型直流等离子体原子发射光谱仪测定血清中Zn、Mn、Al、Cd、Fe、Mg、Ca、Pb、Cu、Se、Ni、Ti、Co、Li、Cr等15种微量元素的含量。乳腺癌患者血清镉水平明显高于正常人，（p = 0.000），镁（p = 0.001），铜（p = 0.000），Co（p = 0.006），Li（p = 0.003）和临界较高Cr（p = 0.052），而Mn（p = 0.000）、Al（p = 0.000）、Fe（p = 0.000）和Ti（p = 0.000）显著低于其匹配对照。然而，两组之间的血清Zn（p = 0.824）、Ca（p = 0.711）、Pb（p = 0.274）、Se（p = 0.236）和Ni（p = 0.185）水平无显著差异。我们的研究表明，在中国东部地区，血清微量元素水平与乳腺癌风险之间可能存在相关性，但需要进一步的调查来证实这种相关性。如果得到证实，微量元素的调节可能有助于降低乳腺癌风险。
Experimental and epidemiological studies suggest that serum levels of trace elements may be associated with breast cancer risk. We compared serum levels of 15 trace elements between breast cancer patients and normal controls from Shandong, China, for the first time to assess whether serum levels of trace elements were associated with breast cancer risk. Eighty-eight breast cancer patients and 84 healthy controls were enrolled in the study. A Spectraspan V direct current plasma atomic emission spectrometer was used to determine the serum levels of 15 trace elements including Zn, Mn, Al, Cd, Fe, Mg, Ca, Pb, Cu, Se, Ni, Ti, Co, Li, and Cr. Breast cancer patients had significantly higher serum levels of Cd (p = 0.000), Mg (p = 0.001), Cu (p = 0.000), Co (p = 0.006), and Li (p = 0.003) and borderline higher Cr (p = 0.052), while significantly lower Mn (p = 0.000), Al (p = 0.000), Fe (p = 0.000), and Ti (p = 0.000) compared to their matched controls. However, there were no significant differences in serum levels of Zn (p = 0.824), Ca (p = 0.711), Pb (p = 0.274), Se (p = 0.236), and Ni (p = 0.185) between the two groups. Our study showed a possible association between serum levels of trace elements and breast cancer risk in eastern China, though it warrants further investigations to confirm the association. If confirmed, modulation of trace elements may help reduce breast cancer risk.