Resuscitation of the monkey brain after one hour's complete ischemia. II. Brain water and electrolytes
Resuscitation of the monkey brain after one hour's complete ischemia. II. Brain water and electrolytes
复制标题
完全缺血一小时后猴脑的复苏。
DOI：
10.1016/0006-8993(75)90997-x
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发表时间：
1975
期刊：
影响因子：
2.9
通讯作者：
K. Hossmann
中科院分区：
文献类型：
--
作者：
V. Zimmermann;K. Hossmann
成年正常体温的恒河猴接受1小时的完全脑缺血，随后进行45分钟至24小时的血液再循环。通过电生理记录监测缺血的功能影响和随后的恢复，并在具有功能恢复迹象的动物和没有恢复的动物之间进行区分。缺血前灰质含水量为81.1 ± 0.3%（平均值±标准差）。白色物质占68.9 ± 0.8%。灰质钠钾比为0.43 ± 0.02，白色质钠钾比为0.62 ± 0.06。缺血1小时脑组织含水量无明显变化，但白色和灰质钠钾比值差异减小。缺血后脑的血液再循环引起脑含水量的显著增加和钠钾比的变化高达1.0。计算的脑肿胀是最大的45分钟后，当它达到总脑体积的11.1%，在一只动物的恢复和12.2%，在另一个没有recovery.In动物的迹象功能恢复脑肿胀迅速减少，随后在24小时内，脑电解质更逐步正常化。在没有功能恢复的动物中，电解质变化是不可逆的，甚至进一步发展。可以得出结论，脑缺血一小时后的脑肿胀和电解质紊乱是完全可逆的，当功能恢复的迹象出现和脑代谢的回报。
Adult normothermic rhesus monkeys were submitted to one hour's complete cerebral ischemia, followed by periods of blood recirculation varying from 45 min to 24 h. The functional impact of ischemia and the subsequent recovery was monitored by electrophysiological recording and a distinction was made between animals with signs of functional recovery and animals without recovery. Prior to ischemia the water content of the gray matter was 81.1 ± 0.3% (mean ± S.D.) and of the white matter 68.9 ± 0.8%. The sodium-potassium ratio in the gray matter was 0.43 ± 0.02 and in the white matter 0.62 ± 0.06. During one hour's ischemia brain water did not change significantly, but the differences in the sodium-potassium ratio in white and gray matter were reduced. Blood recirculation of the brain after ischemia caused a considerable increase in brain water content and a shift in the sodium-potassium ratio up to 1.0. Calculated brain swelling was maximal after 45 min when it reached 11.1% of the total brain volume in an animal with recovery and 12.2% in another one without recovery.In animals with signs of functional recovery brain swelling rapidly diminished, followed by a more gradual normalization of brain electrolytes within 24 h. In animals without functional recovery electrolyte shifts were irreversible or even progressed further. It is concluded that brain swelling and electrolyte derangements following one hour's cerebral ischemia are fully reversible when signs of functional recovery appear and brain metabolism returns.