A comparison between GATE4 results and MCNP4B published data for internal radiation dosimetry
A comparison between GATE4 results and MCNP4B published data for internal radiation dosimetry
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DOI：
10.3413/nukmed-0363-10-10
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
A. Parach;H. Rajabi
中科院分区：
文献类型：
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作者：
A. Parach;H. Rajabi
摘要目的：GATE被设计为GEANT 4工具包的上层，用于核医学应用，包括内部剂量测定。然而，它的结果还没有完全比较发达的代码和拟人化体素幻影从来没有被用于GATE/GEANT的内部剂量测定。本研究的目的是将GATE/GEANT计算的内照射剂量与MCNP 4 B公布的数据进行比较。方法：采用Zubal体模对典型成年男性进行建模。假设活性均匀分布在肝、肾、肺、脾、胰腺和肾上腺中。GATE/ GEANT Monte Carlo软件包用于估算体模中的剂量。对0.01-1 MeV的光子能量和935 keV的单能电子进行了模拟。计算了光子的特定吸收分数和电子的S因子。结果如下：平均而言，GATE/GEANT产生较高的光子SAF（特定吸收分数）值（+2.7%）的自吸收和较低的值（-2.9%）的交叉吸收。配对器官的差异更大，特别是肺。此外，与GATE相比，MCNP 4 B在200和500 keV能量下作为源器官的肺的光子SAF值显著更高。结论：GATE 4与MCNP 4 B虽然存在一定差异，但其结果是可靠的。这可以被认为是GATE/GEANT作为放射性核素剂量测定应用的核医学专有代码的验证。
Summary Aim: GATE, has been designed as upper layer of the GEANT4 toolkit for nuclear medicine application including internal dosimetry. However, its results have not been fully compared to the well-developed codes and anthropomorphic voxel phantoms have never been used with GATE/GEANT for internal dosimetry. The aim of present study was to compare the internal dose calculated by GATE/GEANT with the MCNP4B published data. Methods: The Zubal phantom was used to model a typical adult male. Activity was assumed uniformly distributed in liver, kidneys, lungs, spleen, pancreas and adrenals. GATE/ GEANT Monte Carlo package was used for estimation of doses in the phantom. Simulations were performed for photon energy of 0.01–1 MeV and mono-energetic electrons of 935 keV. Specific absorbed fractions for photons and S-factors for electrons were calculated. Results: On average, GATE/GEANT produces higher photon SAF (Specific Absorbed Fraction) values (+2.7%) for self-absorption and lower values (-2.9%) for cross-absorption. The difference was higher for paired organs particularly lungs. Moreover the photon SAF values for lungs as source organ at the energy of 200 and 500 keV was considerably higher with MCNP4B compared to GATE. Conclusion: Despite of differences between the GATE4 and MCNP4B, the results can be considered ensuring. This may be considered as validation of GATE/GEANT as a proprietary code in nuclear medicine for radionuclide dosimetry applications.