Association between alcohol intake, overweight, and serum lipid Levels and the risk analysis associated with the development of dyslipidemia
Association between alcohol intake, overweight, and serum lipid Levels and the risk analysis associated with the development of dyslipidemia
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DOI：
10.1016/j.jacl.2014.02.003
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发表时间：
2014-06-01
影响因子：
4.4
通讯作者：
Li, Youming
中科院分区：
文献类型：
--
作者：
Shen, Zhe;Munker, Stefan;Li, Youming
背景技术背景：酒精、超重和脂代谢参与脂肪肝和动脉粥样硬化的发病机制。目的：研究酒精摄入、超重和血脂异常之间的关系。性别、年龄、教育程度、吸烟、高血压、每日饮酒量、饮酒时间和体重指数（BMI）与甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-cholesterol.Results：8个疾病预测因子与血脂异常之间的相关性通过广义相加模型进行回归分析。结果显示，年龄、每日饮酒量和BMI均与高脂血症密切相关。年龄、饮酒时间和BMI都与高胆固醇血症密切相关。年龄和BMI状态均与高LDL-C水平密切相关。相比之下，8个预测因子中没有一个与低HDL-C水平密切相关（均P <0.05）。结论：每日饮酒是高脂血症的危险因素。相比之下，饮酒时间是高胆固醇血症的保护因素。年龄和BMI是血脂异常（不包括HDL-C）的重要危险因素。(C)2014年国家脂质协会。All rights reserved.
BACKGROUND: Alcohol, overweight, and lipid metabolism contribute to fatty liver and atherosclerosis pathogenesis.OBJECTIVE: To study the association of alcoholic intake, overweight, and dyslipidemia.METHODS: We randomly selected 482 age- and sex-matched individuals from East China. Gender, age, education level, smoking, hypertension, daily alcohol intake, drinking duration, and body mass index (BMI) were evaluated in association with triglyceride, total cholesterol, high-density (HDL-C), and low-density lipoprotein-cholesterol.RESULTS: The association between dyslipidemia and 8 predictors of disease was made by regression analysis through the generalized additive model. The results showed that age, daily alcohol intake, and BMI were all closely associated with hypertriglyceridemia. Age, duration of drinking, and BMI were all closely associated with hypercholesterolemia. Age and BMI status were both closely associated with high LDL-C levels. By contrast, none of the 8 predictors was closely associated with low HDL-C levels (all P < .05).CONCLUSIONS: Daily alcohol intake was a risk factor for hypertriglyceridemia. By contrast, drinking duration was a protective factor against hypercholesterolemia. Age and BMI were important risk factors for dyslipidemia (excluding HDL-C). (C) 2014 National Lipid Association. All rights reserved.