Vitamin C supplementation and common cold symptoms:: factors affecting the magnitude of the benefit
Vitamin C supplementation and common cold symptoms:: factors affecting the magnitude of the benefit
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DOI：
10.1054/mehy.1997.0639
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发表时间：
1999-02-01
影响因子：
4.7
通讯作者：
Hemilä, H
中科院分区：
文献类型：
--
作者：
Hemilä, H
安慰剂对照试验表明，补充维生素 C 可缩短普通感冒感染的持续时间和严重程度。然而，益处的大小差异很大，阻碍了关于维生素临床意义的结论。本文对 23 项定期补充维生素 C（大于或等于 1 克/天）的研究进行了分析，以找出可以解释部分结果差异的因素。结果发现，平均而言，维生素 C 对儿童的益处大于成人。剂量也可能影响益处的大小，与每天 1 克的维生素相比，大于或等于 2 克/天的维生素的平均益处更大。在成人每天服用 1 克维生素 C 的五项研究中，感冒持续时间的中位减少幅度仅为 6%，而在儿童每天服用 2 克维生素 C 的两项研究中，感冒持续时间的中位减少幅度是其四倍，即 26%。这项工作中分析的试验使用了定期补充维生素 C，但可以想象的是，在感冒发作初期开始补充治疗可能会产生类似的益处。由于很少有试验检验治疗性补充剂的效果，且结果各不相同，因此需要进一步的治疗试验来检验维生素 C 在治疗感冒中的作用。
Placebo-controlled trials have shown that vitamin C supplementation decreases the duration and severity of common cold infections. However, the magnitude of the benefit has substantially varied, hampering conclusions about the clinical significance of the vitamin. In this paper, 23 studies with regular vitamin C supplementation (greater than or equal to 1 g/day) were analyzed to find out factors that may explain some part of the variation in the results, It was found that on average, vitamin C produces greater benefit for children than for adults. The dose may also affect the magnitude of the benefit, there being on average greater benefit from greater than or equal to 2 g/day compared to 1 g/day of the vitamin. In five studies with adults administered 1 g/day of vitamin C, the median decrease in cold duration was only 6%, whereas in two studies with children administered 2 g/day the median decrease was four times higher, 26%. The trials analyzed in this work used regular vitamin C supplementation, but it is conceivable that therapeutic supplementation starting early at the onset of the cold episode could produce comparable benefits. Since few trials have examined the effects of therapeutic supplementation and their results have been variable, further therapeutic trials are required to examine the role of vitamin C in the treatment of colds.